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Imaging of early distal tarsal osteoarthritis in Icelandic horses

Ley, Charles J. (2014). Imaging of early distal tarsal osteoarthritis in Icelandic horses. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2014:53
ISBN 978-91-576-8054-9
eISBN 978-91-576-8055-6
[Doctoral thesis]

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Abstract

The early stages of osteoarthritis (OA) are characterised by focal morphological changes that may slowly progress if joint repair fails. Validated, non-invasive and affordable methods to diagnose the early stage of OA in horses are lacking. The objectives of this thesis were to investigate and validate OA detection methods, and describe the morphological OA changes in the distal tarsal region of a group of young Icelandic horses.

Radiography, computed tomography (CT) and magnetic resonance imaging (MRI), light microscopy histology, backscattered electron scanning electron microscopy, and confocal scanning light microscopy were used to investigate osteochondral changes in the joints of the distal tarsal region in 38 two-and-a-half year old Icelandic horses. Radiographs were taken of live horses standing, all other examinations were performed 2-3 months later on non-weight bearing cadaver specimens from the same horses.

The results showed that a novel CT and MRI guidance method for osteochondral tissue sample collection improved detection of early OA changes in centrodistal (distal intertarsal) joints compared to standardised sample collection from predetermined locations. Diagnostic imaging and microscopy showed that early OA morphological changes primarily occur in the articular hyaline and calcified cartilage rather than the subchondral bone. The lesions articular mineralisation front defect, central osteophytes and hyperdense mineralisation front protrusions were described in detail in the joints of the distal tarsal region using combined microscopic imaging of embedded block specimens. A comparison of clinical diagnostic imaging methods found that radiography was equal or better than low-field MRI for the detection of early OA in centrodistal joints. Articular mineralisation front defects were identified as a highly specific imaging feature in radiographs for early OA.

This thesis provides a detailed morphological description of the osteochondral changes occurring in the early stages of OA in the centrodistal joint of Icelandic horses and proposes a validated, non-invasive, cost-effective radiography method for proceeding with future longitudinal studies of early OA in Icelandic horses.

Authors/Creators:Ley, Charles J.
Title:Imaging of early distal tarsal osteoarthritis in Icelandic horses
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :22 August 2014
Volume:2014:53
Number of Pages:105
Papers/manuscripts:
NumberReferences
I.Ley, C.J., Ekman, S., Dahlberg, L.E., Björnsdóttir, S. & Hansson, K. (2013). Evaluation of osteochondral sample collection guided by computed tomography and magnetic resonance imaging for early detection of osteoarthritis in centrodistal joints of young Icelandic horses. American Journal of Veterinary Research 74(6), 874-887.
II.Ley, C.J., Ekman, S., Hansson, K., Björnsdóttir, S. & Boyde, A. (2014). Osteochondral lesions in distal tarsal joints of Icelandic horses reveal strong associations between hyaline and calcified cartilage abnormalities. European Cells and Materials 27, 213-236.
III.Ley, C.J., Björnsdóttir, S., Ekman, S., Boyde, A. & Hansson, K. Detection of early osteoarthritis in the centrodistal joints of Icelandic horses: Evaluation of radiography and low-field magnetic resonance imaging (submitted).
Place of Publication:Uppsala
Publisher:Department of Clinical Sciences, Swedish University of Agricultural Sciences
ISBN for printed version:978-91-576-8054-9
ISBN for electronic version:978-91-576-8055-6
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Agrovoc terms:horses, breeds (animals), joints (body parts), osteoarthritis, limb bones, cartilage, movement disorders, diagnosis, magnetic resonance imaging, tomography, radiography, microscopy
Keywords:magnetic resonance imaging, computed tomography, radiology, radiography, equine, bone spavin, osteoarthrosis, degenerative joint disease, articular cartilage, microscopy
URN:NBN:urn:nbn:se:slu:epsilon-e-2065
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2065
ID Code:11437
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Gunnar Philipssons stipendium (SLU) and Royal Swedish Academy of Agriculture and Forestry and SLU fund for internationalisation of postgraduate studies and Stiftelsen Hästforskning
Deposited By: Charles J. Ley
Deposited On:22 Aug 2014 12:37
Metadata Last Modified:02 Dec 2014 11:08

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