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Neonatal porcine diarrhoea

aspects on aetiology and pathology

Larsson, Jenny (2016). Neonatal porcine diarrhoea. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2016:13
ISBN 978-91-576-8528-5
eISBN 978-91-576-8529-2
[Doctoral thesis]

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Abstract

Diarrhoea in newborn piglets is an old but still relevant problem in pig production globally. During the last decades, reports from a number of countries describe problems with neonatal porcine diarrhoea (NPD) despite the use of previously effective preventive measures. The aim of this thesis was to investigate and characterise the problem with NPD in Swedish piglet-producing herds. The magnitude of the problem was estimated by a questionnaire study distributed to 170 randomly selected herds. A response rate of 58% was achieved. The total herd-level prevalence of NPD, including herds with sporadic cases, was 79.6%, indicating that NPD is a substantial problem. Ten herds affected by NPD were selected for in-depth studies on the potential causes of the diarrhoea. From each herd, five diarrhoeic and two healthy control piglets were selected. The piglets were blood-sampled for analysis of serum ɣ-globulin, and thereafter euthanized and necropsied. The intestines were sampled for histopathology, virology, and bacteriology. There was no difference in serum ɣ-globulin concentration between diarrhoeic and non-diarrhoeic piglets and pathological lesions in the intestines were generally mild. Porcine enterotoxigenic Escherichia (E.) coli was only found in two piglets. Further, extended virulence gene profiling did not suggest involvement of other diarrhoeagenic pathotypes of E. coli. Clostridium (C.) perfringens type C was not detected, and neither C. perfringens type A nor C. difficile could be related to the diarrhoea. Furthermore, no protozoa such as Cystoisospora suis were observed in the intestinal mucosa. By viral metagenomics analyses of intestinal samples, the only previously well-established porcine enteropathogen found was rotavirus that was present in two herds. Otherwise, the data did not suggest involvement of previously known viruses. The only consistent finding associated with diarrhoea was small intestinal colonisation by Enterococcus (E.) hirae. Enteroadherent E. hirae was detected in 60% of the diarrhoeic piglets from six of the herds and was associated with small intestinal mucosal lesions in more than 50% of the cases (10/18). Thus, our results show that diarrhoea in newborn piglets may have other causes than the well-established pathogens previously associated with NPD and a potential involvement of E. hirae is suggested.

Authors/Creators:Larsson, Jenny
Title:Neonatal porcine diarrhoea
Subtitle:aspects on aetiology and pathology
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :2016
Depositing date:2016
Volume:2016:13
Number of Pages:96
Papers/manuscripts:
NumberReferences
ILarsson, J., Fall, N., Lindberg, M. & Jacobson, M. (2016). Farm characteristics and management routines related to neonatal porcine diarrhoea: a survey among Swedish piglet producers. In manuscript.
IILarsson, J., Aspán, A., Lindberg, R., Grandon, R., Båverud, V., Fall, N. & Jacobson, M. (2015). Pathological and bacteriological characterization of neonatal porcine diarrhoea of uncertain aetiology. Journal of Medical Microbiology 64(8), 916-926.
IIIKarlsson, O.*, Larsson, J.*, Hayer, J., Berg, M. & Jacobson, M. (2016). The intestinal eukaryotic virome in healthy and diarrhoeic neonatal piglets. Manuscript submitted to PLoS One.
IVLarsson, J., Linberg, R., Aspán, A., Grandon, R., Westergren, E. & Jacobson, M. (2014). Neonatal piglet diarrhoea associated with enteroadherent Enterococcus hirae. Journal of Comparative Pathology 151(2-3), 137-147.
Place of Publication:Uppsala
Publisher:Department of Clinical Sciences, Swedish University of Agricultural Sciences
ISBN for printed version:978-91-576-8528-5
ISBN for electronic version:978-91-576-8529-2
ISSN:1652-6880
Language:English
Additional Information:Name of the project: Spädgrisdiarré - ett nygammalt och allvarligt problem i moderna grisbesättningar
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
Agrovoc terms:swine, piglets, newborn animals, diarrhoea, enterococcus hirae, escherichia coli, clostridium perfringens, clostridium difficile, rotavirus, aetiology, pathology
Keywords:Enterococcus hirae, Escherichia coli, ETEC, Clostridium perfringens, Clostridium difficile, rotavirus, viral metagenomics, neonate, pig, swine, NNPD
URN:NBN:urn:nbn:se:slu:epsilon-e-3200
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-3200
ID Code:13024
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Stiftelsen Lantbruksforskning
Deposited By: Jenny Larsson
Deposited On:08 Feb 2016 08:00
Metadata Last Modified:17 Feb 2016 17:30

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