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New aspects of canine pyometra

studies on epidemiology and pathogenesis

Hagman, Ragnvi (2004). New aspects of canine pyometra. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae. Veterinaria, 1401-6257 ; 182
ISBN 91-576-6682-2
[Doctoral thesis]



Pyometra is a common and lethal disease in bitches characterised by uterine bacterial infection leading to subsequent systemic illness. The objectives of the present thesis were to investigate the incidence of the disease in relation to breed and age, to assess bacteriological aspects of pyometra and to evaluate the involvement of endotoxin and prostaglandin F2α in the pathogenesis. Animal insurance data revealed age- and breed-dependent differences in the incidence of pyometra. On average 23-24% of all bitches studied experienced pyometra before 10 years of age. Data presented in this study indicate that certain breeds have a genetic pre-disposition for pyometra. Bacteriological genotype examinations showed that pyometra is most likely caused by Escherichia coli clones originating from the normal flora of each dog, i.e. not by clones spreading between animals. The resistance among E. coli isolates from pyometra bitches against antimicrobials commonly used in canine practice was low and not likely to cause therapy failure. Data on antimicrobial resistance of E. coli from urinary tract infections were generally not suitable for selecting antimicrobial treatment of pyometra. Systemic endotoxemia was confirmed in bitches with pyometra. The plasma levels of endotoxin were correlated with concentrations of the prostaglandin F2α metabolite (PG-metabolite). This indicates the usefulness of PG-metabolite in the diagnosis of endotoxemia in bitches. Bitches with pyometra also had increased blood concentrations of PG-metabolite compared with bitches with cystic endometrial hyperplasia (CEH). The present study revealed that in bitches with fluid in the uterus, the analysis of PG-metabolite in combination with percentage band neutrophils can distinguish between pyometra and CEH. The levels of PG-metabolite are predictive of the severity of pyometra since they were correlated to criteria of a systemic inflammatory response and also to the length of hospitalisation. In summary, this thesis provides data on breed- and age-related differences in the incidence of pyometra, which will be helpful in future studies of the disease and breeding programmes. In addition, clarification of key bacteriological and pathophysiological characteristics of the development of pyometra can improve diagnostic and therapeutic strategies and increase survival rates.

Authors/Creators:Hagman, Ragnvi
Title:New aspects of canine pyometra
Subtitle:studies on epidemiology and pathogenesis
Year of publishing :2004
Number of Pages:55
I.Egenvall, A., Hagman, R., Bonnett, B.N., Hedhammar, Å., Olsson, P. and Lagerstedt, A.-S. 2001. Breed risk of pyometra in insured dogs in Sweden. Journal of Veterinary Internal Medicine 15, 530-538.
II.Hagman, R. and Kühn, I. 2002. Escherichia coli strains isolated from the uterus and urinary bladder of bitches suffering from pyometra: comparison by restriction enzyme digestion and pulsed-field gel electrophoresis. Veterinary Microbiology 84, 143-153.
III.Hagman, R. and Greko, C. 2004. Antimicrobial resistance in Escherichia coli from canine pyometra and urinary tract infections. The Veterinary Record (In press).
IV.Hagman, R., Kindahl, H. and Lagerstedt, A.-S. 2004. Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F2α metabolite levels. (Manuscript submitted for publication).
V.Hagman, R., Kindahl, H., Fransson, B.A., Bergström, A., Ström Holst, B. and Lagerstedt, A.-S. 2004. Differentiation between pyometra and cystic endometrial hyperplasia in bitches by prostaglandin F2α metabolite analysis. (Manuscript submitted for publication).
Place of Publication:Uppsala
Publisher:Department of Small Animal Clinical Sciences, Swedish University of Agricultural Sciences
Associated Programs and Other Stakeholders:SLU - Research Areas for the Future > Future Animal Health and Welfare
ISBN for printed version:91-576-6682-2
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:Not in use, please see Agris categories
Agrovoc terms:pyometra, dogs, females, escherichia coli, urinary tract diseases, antibiotics, breeds (animals)
Keywords:Pyometra, dogs, cystic endometrial hyperplasia, Escherichia coli, urinary tract infection, pulsed-field gel electrophoresis, lipo-polysaccharide, limulus amoebocyte lysate assay, minimum inhibitory concentration, antibiotics
Permanent URL:
ID Code:736
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Deposited By: Ragnvi Hagman
Deposited On:18 Jan 2005 00:00
Metadata Last Modified:02 Dec 2014 10:06

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