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Particulate airborne impurities

express analysis and health effects

Wilkinson, Kai (2013). Particulate airborne impurities. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis Agriculturae Sueciae, 1652-6880 ; 2013:27
ISBN 978-91-576-7792-1
eISBN 978-91-576-7793-8
[Doctoral thesis]

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The cumulative effects of air pollutants are of principal concern in research on environmental protection in Sweden. Post-industrial society has imposed many limits on emitted air pollutants, yet the number of reports on the negative effects from them is increasing, largely due to human activity in the form of industrial emissions and increased traffic flows. Rising concerns over the health effects from airborne particulate matter (PM) stem from in vitro, in vivo, and cohort studies revealing effects of mostly negative nature.

Full insight into the health effects from PM can only be achieved through practical investigation of the mode of toxicity from distinct types of particles and requires techniques for their identification, monitoring, and the production of model fractions for health studies.
To this effect, comprehensive collection and chemical analysis of particulates at the origin of emission was performed in order to provide clearer insight into the nature of the particulates at exposure and add detail to aid risk assessment. Methods of capturing particles and analyzing their chemical nature were devised using scanning electron microscopy coupled with energy dispersive spectroscopy (SEM-EDS).

Furthermore, taking the approach of in vitro cytotoxicity testing, nanoparticles of types typical to automotive emissions, were synthesized and extensively characterized using SEM-EDS, X-ray diffraction (XRD), transmission electron microscopy (TEM),dynamic light scattering (DLS), and nanoparticle tracking analysis (NTA). The produced model magnetite and palladium nanoparticles were found to induce toxicity in human pulmonary epithelial cells (A549 and PBEC) as well as impact severely on immunological and renal cells (221 B- and 293T-cells) in a dose-dependent manner.

Authors/Creators:Wilkinson, Kai
Title:Particulate airborne impurities
Subtitle:express analysis and health effects
Series Name/Journal:Acta Universitatis Agriculturae Sueciae
Year of publishing :2013
Number of Pages:75
I.Wilkinson, K.; Lundkvist, J.; Seisenbaeva, G.; Kessler, V. (2011). New Tabletop SEM-EDS-Based Approach for Cost-Efficient Monitoring of Airborne Particulate Matter. Environ Pollut, 159, pp. 311-318.
II.Wilkinson, K.; Lundkvist, J.; Netrval, J.; Eriksson, M.; Seisenbaeva, G.; Kessler, V. (manuscript). Space and Time Resolved Monitoring of Airborne Particulate Matter in Proximity of a Traffic Roundabout in Sweden.
III.Wilkinson, K. E.; Palmberg, L.; Witasp, E.; Kupczyk, M.; Feliu, N.; Gerde, P.; Seisenbaeva, G. A.; Fadeel, B.; Dahlén, S.-E.; Kessler, V. G. (2011). Solution-Engineered Palladium Nanoparticles: Model for Health Effect Studies of Automotive Particulate Pollution. ACS Nano, 5(7), pp. 5312-5324.
IV.Wilkinson, K.; Ekstrand-Hammarström, B.; Ahlinder, L.; Guldevall, K.; Pazik, R.; Kepinski, L.; Kvashnina, K. O.; Butorin, S. M.; Brismar, H.; Önfelt, B.; Österlund, L.; Seisenbaeva, G. A.; Kessler, V. G. (2012). Visualization of Custom-Tailored Iron Oxide Nanoparticles Chemistry, Uptake, and Toxicity. Nanoscale, 4(23), pp. 7383.7393
Place of Publication:Uppsala
Publisher:Department of Chemistry, Swedish University of Agricultural Sciences
ISBN for printed version:978-91-576-7792-1
ISBN for electronic version:978-91-576-7793-8
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:T Pollution > T01 Pollution
X Agricola extesions > X50 Chemistry
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 104 Chemical Sciences > Inorganic Chemistry
(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmacology and Toxicology
Agrovoc terms:air pollution, pollutants, particle size, toxicity, health hazards, analytical methods, monitoring
Keywords:air pollution, particulate matter, PM, nanoparticle, toxicity, monitoring, SEM-EDS, TEM
Permanent URL:
ID Code:10065
Department:(NL, NJ) > Dept. of Chemistry (until 131231)
Deposited By: Kai Wilkinson
Deposited On:04 Apr 2013 08:38
Metadata Last Modified:11 Oct 2016 08:15

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