characteristic profiles and parameter identification
Peletier, Lambertus A. and Gabrielsson, Johan
(2012).
Dynamics of target-mediated drug disposition.
Journal of pharmacokinetics and pharmacodynamics. 39
:5
, 429-51
[Journal article]
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Official URL: http://dx.doi.org/10.1007/s10928-012-9260-6
Abstract
In this paper we present a mathematical analysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligand to target, we give a qualitative characterisation of ligand versus time graphs for different dosing regimes and derive accurate analytic approximations of different phases in the temporal behaviour of the system. These approximations are used to estimate model parameters, give analytical approximations of such quantities as area under the ligand curve and clearance. We formulate conditions under which a suitably chosen Michaelis-Menten model provides a good approximation of the full TMDD-model over a specified time interval.
Authors/Creators: | Peletier, Lambertus A. and Gabrielsson, Johan | ||||
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Title: | Dynamics of target-mediated drug disposition | ||||
Subtitle: | characteristic profiles and parameter identification | ||||
Series/Journal: | Journal of pharmacokinetics and pharmacodynamics (1567-567X) | ||||
Year of publishing : | 2012 | ||||
Volume: | 39 | ||||
Number: | 5 | ||||
Page range: | 429-51 | ||||
Number of Pages: | 23 | ||||
Publisher: | Springer Verlag | ||||
ISSN: | 1567-567X | ||||
Language: | English | ||||
Additional Information: | Payed Open Access | ||||
Publication Type: | Journal article | ||||
Refereed: | Yes | ||||
Article category: | Scientific peer reviewed | ||||
Version: | Published version | ||||
Full Text Status: | Public | ||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmacology and Toxicology (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmaceutical Sciences | ||||
Keywords: | Target , Receptor, Antibodies, Drugdisposition, Michaelis–Menten , Quasi-steady-state, Quasi-equilibrium , Singular perturbation | ||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-1504 | ||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-1504 | ||||
Additional ID: |
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ID Code: | 10485 | ||||
Department: | (VH) > Dept. of Biomedical Sciences and Veterinary Public Health | ||||
Deposited By: | SLUpub Connector | ||||
Deposited On: | 18 Jun 2013 07:49 | ||||
Metadata Last Modified: | 30 Mar 2015 22:04 |
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