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Dynamics of target-mediated drug disposition

characteristic profiles and parameter identification

Peletier, Lambertus A. and Gabrielsson, Johan (2012). Dynamics of target-mediated drug disposition. Journal of pharmacokinetics and pharmacodynamics. 39:5, 429-51
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Official URL: http://dx.doi.org/10.1007/s10928-012-9260-6

Abstract

In this paper we present a mathematical analysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligand to target, we give a qualitative characterisation of ligand versus time graphs for different dosing regimes and derive accurate analytic approximations of different phases in the temporal behaviour of the system. These approximations are used to estimate model parameters, give analytical approximations of such quantities as area under the ligand curve and clearance. We formulate conditions under which a suitably chosen Michaelis-Menten model provides a good approximation of the full TMDD-model over a specified time interval.

Authors/Creators:Peletier, Lambertus A. and Gabrielsson, Johan
Title:Dynamics of target-mediated drug disposition
Subtitle:characteristic profiles and parameter identification
Series/Journal:Journal of pharmacokinetics and pharmacodynamics (1567-567X)
Year of publishing :2012
Volume:39
Number:5
Page range:429-51
Number of Pages:23
Publisher:Springer Verlag
ISSN:1567-567X
Language:English
Additional Information:Payed Open Access
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmacology and Toxicology
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmaceutical Sciences
Keywords:Target , Receptor, Antibodies, Drugdisposition, Michaelis–Menten , Quasi-steady-state, Quasi-equilibrium , Singular perturbation
URN:NBN:urn:nbn:se:slu:epsilon-e-1504
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-1504
Additional ID:
Type of IDID
Web of Science (WoS)000308962200002
ID Code:10485
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:18 Jun 2013 07:49
Metadata Last Modified:30 Mar 2015 22:04

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