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The anorectic response to growth hormone in obese rats is associated with increased ketogenesis: a short communication

Xu, Bo and Manubolu, Manjunath and Dutta, Paresh and Malmlöf, Kjell (2013). The anorectic response to growth hormone in obese rats is associated with increased ketogenesis: a short communication. Open journal of molecular and integrative physiology. 3:2, 80-82
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Official URL: http://dx.doi.org/10.4236/ojmip.2013.32012

Abstract

The purpose of this study was to investigate whether
obese rats with a strong anorectic response to growth
hormone also showed signs of increased hepatic ketogenesis
as reflected in circulating β-hydroxybutyrate
levels. Rats with diet-induced obesity were allocated
to one of two groups, receiving either vehicle
(n = 7) or 4 mg/kg/d of growth hormone (n = 13) for 4
days. This latter group was later split into a group of
responders (n = 8) showing a cumulated reduction of
food intake of more than 4 g from base line during
the last two days of administrations and a group of
non-responders (n = 5). The cumulated reduction of
food intake from baseline among the responders was
10.8 ± 1.5 g. The corresponding marginal reductions
in the non-responder and vehicle groups were 0.5 ±
3.4 g and 0.5 ± 3.7 g, respectively. Growth hormone
administration generally increased serum levels of β-
hydroxybutyrate and free fatty acids, compared with
vehicle, whereas triglycerides were decreased. Among
the responders this effect was statistically significant
in all instances whereas the same trend was weaker
among non-responders. The main finding of the present
study was that the serum β-hydroxybutyrate levels
of 0.76 ± 0.11 mmol/l among responders was three
times higher than non-responders (p < 0.01). In conclusion,
the present study suggests that increased hepatic
ketogenesis is an important component in the
mechanism by which growth hormone inhibits food
intake in rats with an obese phenotype. The precise
molecular mechanisms, however, remain to be elucidated.

Authors/Creators:Xu, Bo and Manubolu, Manjunath and Dutta, Paresh and Malmlöf, Kjell
Title:The anorectic response to growth hormone in obese rats is associated with increased ketogenesis: a short communication
Series/Journal:Open journal of molecular and integrative physiology (2162-2167)
Year of publishing :2013
Volume:3
Number:2
Page range:80-82
Number of Pages:3
Publisher:Scientific Research Publishing, Inc.
ISSN:2162-2167
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:X Agricola extesions > X30 Life sciences
X Agricola extesions > X50 Chemistry
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology
Keywords:Growth Hormone , Lipolysis;, Ketogenesis, Food Intake
URN:NBN:urn:nbn:se:slu:epsilon-e-1514
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-1514
ID Code:10534
Department:(NL, NJ) > Dept. of Food Science (until 161231)
(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:27 Jun 2013 13:33
Metadata Last Modified:06 Feb 2016 09:09

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