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The wild male mink as a sentinel for endocrine-disrupting chemicals and reproductive toxicity

Persson, Sara (2013). The wild male mink as a sentinel for endocrine-disrupting chemicals and reproductive toxicity. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2013:65
ISBN 978-91-576-7868-3
eISBN 978-91-576-7869-0
[Doctoral thesis]

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Abstract

Increasing evidence indicates that pollutants may affect the hormone system of humans and wildlife. These endocrine-disrupting chemicals are related to an increased risk of a
variety of diseases and disorders, including adverse effects on the reproductive system. By using a sentinel wildlife species, an early warning of adverse health effects due to pollutants in the environment may be provided. This is also relevant for humans, as wildlife and humans can be exposed to similar mixtures of pollutants.

With this in mind, the aim of this thesis is to investigate the possibility of establishing the wild mink (Neovison vison) as a sentinel species in Sweden, for both exposure to pollutants and effects of pollutants on the reproductive system. Mink were collected from local hunters and necropsies were performed focusing on the male reproductive system. The collected mink provided an insight in how to handle the variation in data due to sample season, age and nutritional status. These factors significantly influenced many, but not all, of the concentrations of chlorinated,
brominated and perfluorinated compounds and also some reproductive organ variables. In addition, the results offer information on how to optimize the design of future
studies, and some baseline data for reproductive organ measurements were compiled. Considerable concentrations of PCBs were found in some areas and the concentrations
of PFOS were among the highest ever recorded in mink. Associations were found between measurements on the reproductive organs and pollutant concentrations. The
anogenital distance was inversely associated with concentrations of some perfluoroalkyl acids and DDE. Several associations were also found between some
PCB congeners and measurements on the penis and baculum.

In conclusion, the wild mink males may serve as an indicator for environmental exposure to pollutants in Sweden. In addition, the wild mink seems to be a suitable
sentinel species that may provide an early warning of alterations in the male reproductive organs related to environmental pollution.

Authors/Creators:Persson, Sara
Title:The wild male mink as a sentinel for endocrine-disrupting chemicals and reproductive toxicity
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :2013
Volume:2013:65
Number of Pages:55
Papers/manuscripts:
NumberReferences
I.Persson, S., Bäcklin, B.-M., Kindahl, H., Brunström, B. & Magnusson, U. (2011). Influence of age, nutritional status and season on the reproductive system in wild male mink (Neovison vison). European Journal of Wildlife Research 57(5), 1057-1063.
II.Persson, S., Rotander, A., van Bavel, B., Brunström, B., Bäcklin, B.-M. & Magnusson, U. (2013). Influence of age, season, body condition and geographical area on concentrations of chlorinated and brominated contaminants in wild mink (Neovison vison) in Sweden. Chemosphere 90(5), 1664-1671.
III.Persson, S., Rotander, A., Kärrman, A., van Bavel, B. & Magnusson, U. (2013). Perfluoroalkyl acids in subarctic wild male mink (Neovison vison) in relation to age, season and geographical area. Environment International 59, 425-430.
IV.Persson, S., & Magnusson, U. Environmental pollutants and alterations in the reproductive system in wild male mink (Neovison vison) from Sweden (manuscript).
Place of Publication:Uppsala
Publisher:Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
Associated Programs and Other Stakeholders:SLU - Environmental assessment > Programme Non-Toxic Environment
SLU - Research Areas for the Future > Future Animal Health and Welfare
ISBN for printed version:978-91-576-7868-3
ISBN for electronic version:978-91-576-7869-0
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L53 Animal physiology - Reproduction
L Animal production > L74 Miscellaneous animal disorders
T Pollution > T01 Pollution
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 104 Chemical Sciences > Organic Chemistry
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 405 Other Agricultural Sciences > Environmental Sciences related to Agriculture and Land-use
Agrovoc terms:minks, males, wild animals, indicator animals, reproductive disorders, endocrine glands, pollutants, toxic substances, chemical compounds, polychlorinated biphenyls, organobromine compounds, dde
Keywords:mink, endocrine-disrupting chemicals, male reproduction, PCB, PBDE, perfluoroalkyl acids, PFOS, DDE, anogenital distance, penis, baculum
URN:NBN:urn:nbn:se:slu:epsilon-e-1643
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-1643
ID Code:10814
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: Sara Persson
Deposited On:25 Sep 2013 13:25
Metadata Last Modified:14 Dec 2014 13:11

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