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Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis

Karlsson, Iulia and Wernersson, Sara and Ambrosen, Aime and Kindahl, Hans and Södersten, Fredrik and Wang, Liya and Hagman, Ragnvi (2013). Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis. Veterinary immunology and immunopathology. 156:1-2, 64-72
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Abstract

Sepsis is difficult to diagnose and remains a common mortality cause worldwide in both humans and animals. The uterine infection pyometra causes sepsis in more than half of affected dogs and therefore allows the natural physiological development of sepsis to be studied. To find a sepsis-specific biochemical marker that could be combined with conventional clinical criteria for a more robust and quick diagnosis of sepsis, we measured systemic concentrations of high-mobility group box 1 (HMGB1) in 23 healthy control dogs and in 27 dogs with pyometra, 74% of which had sepsis. We also measured concentrations of the major acute phase protein C-reactive protein (CRP) and an indicator for endotoxaemia, prostaglandin F-2 alpha metabolite (PGM) to assess the relative contribution of HMGB1 to the detection of systemic inflammation and endotoxaemia. We found that HMGB1 concentrations, in line with concentrations of CRP and PGM, were significantly increased in dogs with pyometra, and that concentrations of CRP, but not HMGB1, were significantly higher in dogs with sepsis compared to dogs without sepsis. Although serum HMGB1 did not differ between dogs with or without sepsis and was not correlated with either CRP or PGM concentrations, HMGB1 was correlated with the total white blood cell counts, suggesting an independent regulation and involvement in inflammation. (C) 2013 Elsevier B.V. All rights reserved.

Authors/Creators:Karlsson, Iulia and Wernersson, Sara and Ambrosen, Aime and Kindahl, Hans and Södersten, Fredrik and Wang, Liya and Hagman, Ragnvi
Title:Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis
Series/Journal:Veterinary immunology and immunopathology (0165-2427)
Year of publishing :September 2013
Volume:156
Number:1-2
Page range:64-72
Number of Pages:9
Publisher:Elsevier
ISSN:0165-2427
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Immunology (Immunology in the medical area to be 30110)
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Infectious Medicine
Keywords:Sepsis, SIRS, Biomarkers, Diagnostics, Cytokines, Canine/dog, Pyometra, Bacterial uterine infection, Inflammation, HMGB1, CRP, PGM
URN:NBN:urn:nbn:se:slu:epsilon-e-1929
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-1929
Additional ID:
Type of IDID
Web of Science (WoS)000327572500006
DOI10.1016/j.vetimm.2013.09.011
ID Code:11153
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:26 May 2014 12:04
Metadata Last Modified:05 Dec 2014 22:04

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