Karlsson, Iulia and Wernersson, Sara and Ambrosen, Aime and Kindahl, Hans and Södersten, Fredrik and Wang, Liya and Hagman, Ragnvi
(2013).
Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis.
Veterinary immunology and immunopathology. 156
:1-2
, 64-72
[Journal article]
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- Accepted Version
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Abstract
Sepsis is difficult to diagnose and remains a common mortality cause worldwide in both humans and animals. The uterine infection pyometra causes sepsis in more than half of affected dogs and therefore allows the natural physiological development of sepsis to be studied. To find a sepsis-specific biochemical marker that could be combined with conventional clinical criteria for a more robust and quick diagnosis of sepsis, we measured systemic concentrations of high-mobility group box 1 (HMGB1) in 23 healthy control dogs and in 27 dogs with pyometra, 74% of which had sepsis. We also measured concentrations of the major acute phase protein C-reactive protein (CRP) and an indicator for endotoxaemia, prostaglandin F-2 alpha metabolite (PGM) to assess the relative contribution of HMGB1 to the detection of systemic inflammation and endotoxaemia. We found that HMGB1 concentrations, in line with concentrations of CRP and PGM, were significantly increased in dogs with pyometra, and that concentrations of CRP, but not HMGB1, were significantly higher in dogs with sepsis compared to dogs without sepsis. Although serum HMGB1 did not differ between dogs with or without sepsis and was not correlated with either CRP or PGM concentrations, HMGB1 was correlated with the total white blood cell counts, suggesting an independent regulation and involvement in inflammation. (C) 2013 Elsevier B.V. All rights reserved.
Authors/Creators: | Karlsson, Iulia and Wernersson, Sara and Ambrosen, Aime and Kindahl, Hans and Södersten, Fredrik and Wang, Liya and Hagman, Ragnvi | ||||||
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Title: | Increased concentrations of C-reactive protein but not high-mobility group box 1 in dogs with naturally occurring sepsis | ||||||
Series/Journal: | Veterinary immunology and immunopathology (0165-2427) | ||||||
Year of publishing : | September 2013 | ||||||
Volume: | 156 | ||||||
Number: | 1-2 | ||||||
Page range: | 64-72 | ||||||
Number of Pages: | 9 | ||||||
Publisher: | Elsevier | ||||||
ISSN: | 0165-2427 | ||||||
Language: | English | ||||||
Publication Type: | Journal article | ||||||
Refereed: | Yes | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Accepted version | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Immunology (Immunology in the medical area to be 30110) (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Infectious Medicine | ||||||
Keywords: | Sepsis, SIRS, Biomarkers, Diagnostics, Cytokines, Canine/dog, Pyometra, Bacterial uterine infection, Inflammation, HMGB1, CRP, PGM | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-1929 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-1929 | ||||||
Additional ID: |
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ID Code: | 11153 | ||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
Department: | (VH) > Dept. of Anatomy, Physiology and Biochemistry | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 26 May 2014 12:04 | ||||||
Metadata Last Modified: | 05 Dec 2014 22:04 |
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