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Chromogranins can be measured in samples from cats and dogs

Stridsberg, Mats and Pettersson, Ann and Hagman, Ragnvi and Höglund, Odd (2014). Chromogranins can be measured in samples from cats and dogs. BMC Research Notes. 7:336, 1-4
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Abstract

Background: Methods for objective evaluation of stress in animals are important, but clinically difficult. An alternative method to study the sympathetic activity may be to investigate Chromogranin A (CGA), Chromogranin B (CGB) and Secretogranin II (SG2). The aim of this study was to investigate the cross-reactivity of CGA, CGB and SG2 between man, cat and dog and to explore possibilities to measure these proteins in samples from cats and dogs. Results: Adrenal gland extracts from feline and canine species were measured by region-specific radioimmunoassays in different dilution steps to explore possible inter species cross reactivity. High cross reactivity was found for cats in the CGA17-38, CGA324-337, CGA361-372, CGB and SG2 assays. High cross reactivity was found for dogs in the CGA17-38, CGA361-372, CGB and SN assays. The method measuring the intact CGA was not useful for measurements in cats and dogs. Conclusions: Region-specific assays measuring defined parts of CGA, CGB and SG2 can be used for measurements in samples from cats and dogs. These results are promising and will allow for further studies of these proteins as possible clinical biomarkers in cats and dogs.
Keywords: Chromogranin, Secretogranin, Canine, Feline, Human, Radioimmunoassay

Authors/Creators:Stridsberg, Mats and Pettersson, Ann and Hagman, Ragnvi and Höglund, Odd
Title:Chromogranins can be measured in samples from cats and dogs
Series/Journal:BMC Research Notes (1756-0500)
Year of publishing :2014
Volume:7
Number:336
Page range:1-4
Number of Pages:4
Publisher:BioMed Central Ltd.
ISSN:1756-0500
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Endocrinology and Diabetes
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Medicinal Chemistry
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Physiology
Keywords:Chromogranin, Secretogranin, Canine, Feline, Human, Radioimmunoassay
URN:NBN:urn:nbn:se:slu:epsilon-e-2005
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2005
ID Code:11288
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Amanda Personnes’ Research Fund and Erik, Karin and Gösta Selanders fund and Lions Cancer Foundation and Thure F och Karin Forsbergs stiftelse
Deposited By: SLUpub Connector
Deposited On:04 Jul 2014 09:04
Metadata Last Modified:04 Dec 2014 08:49

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