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Osteochondral lesions in distal tarsal joints of Icelandic horses reveal strong associations between hyaline and calcified cartilage abnormalities

Ley, Charles and Ekman, Stina and Hansson, Kerstin and Björnsdóttir, Sigridur and Boyde, Alan (2014). Osteochondral lesions in distal tarsal joints of Icelandic horses reveal strong associations between hyaline and calcified cartilage abnormalities. European Cells and Materials. 27, 213-236
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Official URL: http://www.ecmjournal.org/journal/papers/vol027/vo...

Abstract

Osteochondral lesions in the joints of the distal tarsal
region of young Icelandic horses provide a natural model
for the early stages of osteoarthritis (OA) in low-motion
joints. We describe and characterise mineralised and
non-mineralised osteochondral lesions in left distal tarsal
region joint specimens from twenty-two 30 ±1 month-old
Icelandic horses. Combinations of confocal scanning light
microscopy, backscattered electron scanning electron
microscopy (including, importantly, iodine staining) and
three-dimensional microcomputed tomography were used
on specimens obtained with guidance from clinical imaging.
Lesion-types were described and classified into groups
according to morphological features. Their locations in
the hyaline articular cartilage (HAC), articular calcified
cartilage (ACC), subchondral bone (SCB) and the joint
margin tissues were identified and their frequency in the
joints recorded. Associations and correlations between
lesion-types were investigated for centrodistal joints only.
In centrodistal joints the lesion-types HAC chondrocyte
loss, HAC fibrillation, HAC central chondrocyte clusters,
ACC arrest and ACC advance had significant associations
and strong correlations. These lesion-types had moderate
to high frequency in centrodistal joints but low frequencies
in tarsometatarsal and talocalcaneal-centroquartal joints.
Joint margin lesion-types had no significant associations
with other lesion-types in the centrodistal joints but high
frequency in both the centrodistal and tarsometatarsal
joints. The frequency of SCB lesion-types in all joints
was low. Hypermineralised infill phase lesion-types were
detected. Our results emphasise close associations between
HAC and ACC lesions in equine centrodistal joints and the
importance of ACC lesions in the development of OA in
low-motion compression-loaded equine joints.

Authors/Creators:Ley, Charles and Ekman, Stina and Hansson, Kerstin and Björnsdóttir, Sigridur and Boyde, Alan
Title:Osteochondral lesions in distal tarsal joints of Icelandic horses reveal strong associations between hyaline and calcified cartilage abnormalities
Series/Journal:European Cells and Materials (1473-2262)
Year of publishing :25 March 2014
Volume:27
Page range:213-236
Publisher:AO Research Institute Davos
ISSN:1473-2262
Language:English
Additional Information:Stiftelsen Hästförskning project name 'Detektionsmetoder för tidiga osteoatritförändringar i hasleden hos islandshästen med hjälp av tre-dimensionella morfometriska parametrar, bilddiagnostisk och molekylära markörer.'
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Agrovoc terms:cartilage, bones, osteoarthritis, tarsus, microscopy, scanning microscopy, tomography
Keywords:articular cartilage, subchondral bone, osteoarthritis, equine tarsus, back scattered electron microscopy, iodine-staining, confocal scanning light microscopy, microcomputed tomography
URN:NBN:urn:nbn:se:slu:epsilon-e-2072
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2072
ID Code:11451
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Carl-Fredrik von Horns fond - KSLA and Royal Swedish Academy of Agriculture and Forestry and Stiftelsen Hästforskning
Deposited By: Charles J. Ley
Deposited On:27 Aug 2014 09:22
Metadata Last Modified:02 Dec 2014 11:08

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