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Ligation of the spermatic cord in dogs with a self-locking device of a resorbable polyglycolic based co-polymer

feasibility and long-term follow-up study

Höglund, Odd and Ingman, Jessica and Södersten, Fredrik and Hansson, Kerstin and Borg, Niklas and Lagerstedt, Anne-Sofie (2014). Ligation of the spermatic cord in dogs with a self-locking device of a resorbable polyglycolic based co-polymer. BMC Research Notes. 7:825, 1-7
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Abstract

Background: New surgical techniques are developed to enable a quicker, easier and safer surgery with reduced risk of complications and shortened time needed for recovery. A resorbable device, a self-locking loop, was designed for surgical ligation. The objective of this pilot study was to investigate the feasibility of ligating the spermatic cord with the device, its biocompatibility and long-term resorption in dogs.  Results: The device was made of a block co-polymer (glycolide and trimethylene carbonate), manufactured by injection moulding and consisted of a flexible band running through a case with a locking mechanism. Ten devices were tested for ligation of the spermatic cords in five dogs admitted for routine neutering. The dogs were monitored by physical examination and ultrasonography of the site of ligation, area of spermatic cord and medial iliac lymph nodes regularly until no hyperechoic remnants of the device or acoustic shadowing or local tissue reactions were observed. Haemostasis of the spermatic cords was achieved with the devices. On ultrasonography the devices were seen as hyperechoic structures for 2 months after neutering causing acoustic shadowing for 1 month. The dogs were monitored for 3 - 5 months after surgery. Gradual decrease in echogenicity and final disappearance of the hyperechoic structures suggested resorption. Macroscopic and histological post mortem examinations were performed in one dog at 3 months after surgery. Post mortem examination showed a tissue reaction of a suture granuloma that was restricted in extent at site of the device. 
Conclusions: The results of this pilot study suggest biocompatibility and indicate that ligation of the spermatic cord is feasible with the device.

Authors/Creators:Höglund, Odd and Ingman, Jessica and Södersten, Fredrik and Hansson, Kerstin and Borg, Niklas and Lagerstedt, Anne-Sofie
Title:Ligation of the spermatic cord in dogs with a self-locking device of a resorbable polyglycolic based co-polymer
Subtitle:feasibility and long-term follow-up study
Series/Journal:BMC Research Notes (1756-0500)
Year of publishing :2014
Volume:7
Number:825
Page range:1-7
Number of Pages:7
Publisher:BioMed Central Ltd
ISSN:1756-0500
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Surgery
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 304 Medical Biotechnology > Biomaterials Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Resorbable medical device, Bioabsorbable, Glycolide, Trimethylene carbonate, Block co-polymer, Castration, Ultrasonography, Replacement, Reduction, Refinement
URN:NBN:urn:nbn:se:slu:epsilon-e-2592
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2592
Additional ID:
Type of IDID
DOI10.1186/1756-0500-7-825
ID Code:12087
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
University Animal Hospital (UAH)
External funders:Amanda Personnes’ Research Fund
Deposited By: SLUpub Connector
Deposited On:23 Apr 2015 11:48
Metadata Last Modified:12 May 2015 20:07

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