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Maxsim2-Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics

Gabrielsson, Johan and Andersson, Kristoffer and Tobin, Gunnar and Ingvast Larsson, Carina and Jirstrand, Mats (2014). Maxsim2-Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics. Computer methods and programs in biomedicine. 113:3, 815-829
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Official URL: http://dx.doi.org/10.1016/j.cmpb.2013.12.006

Abstract

We developed a computer program for use in undergraduate and graduate courses in pharmacology, pharmacokinetics and pharmacodynamics. This program can also be used in environmental and toxicological studies and preclinical simulation, to facilitate communication between modeling pharmacokineticists and project leaders or other decision-makers in the pharmaceutical industry. The program simulates the drug delivery and transport by means of (I) a six-compartment physiological pharmacokinetic flow model, (II) a system of traditional compartment models, or (III) a target-mediated drug disposition system. The program also can be used to simulate instantaneous equilibria between concentration and pharmacodynamic response, or as temporal delays between concentration and response. The latter is done by means of turnover models (indirect response models). Drug absorption, distribution, and elimination are represented by differential equations, which are described by organ and tissue volumes or other volumes of distribution, blood flows, clearance terms, and tissue-to-blood partition coefficients. The user can control and adjust these parameters by means of a slider in real time. By interactively changing the parameter values and simultaneously displaying the resulting concentration-time and/or response-time profiles, users can understand the major mechanisms that govern the disposition or the pharmacological response of the drug in the organism in real time. Schedule dependence is typically seen in clinical practice with a non-linear concentration-response relationship, and is difficult to communicate except via simulations. Here, we sought to illustrate the potential advantages of this approach in teaching pharmacology, pharmacokinetics, and pharmacodynamics to undergraduate pharmacy-, veterinary-, and medical students or to project teams in drug discovery/development.

Authors/Creators:Gabrielsson, Johan and Andersson, Kristoffer and Tobin, Gunnar and Ingvast Larsson, Carina and Jirstrand, Mats
Title:Maxsim2-Real-time interactive simulations for computer-assisted teaching of pharmacokinetics and pharmacodynamics
Series/Journal:Computer methods and programs in biomedicine (0169-2607)
Year of publishing :2014
Volume:113
Number:3
Page range:815-829
Number of Pages:15
Publisher:Elsevier
ISSN:0169-2607
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:X Agricola extesions > X38 Human medicine, health, and safety
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmaceutical Sciences
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmacology and Toxicology
Agrovoc terms:pharmacodynamics, pharmacology
Keywords:Pharmacokinetics, Pharmacodynamics, Pharmacology training, Real time simulations, Interaction, Visualization
URN:NBN:urn:nbn:se:slu:epsilon-e-2603
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2603
Additional ID:
Type of IDID
Web of Science (WoS)000331726500010
ID Code:12097
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:29 Apr 2015 09:33
Metadata Last Modified:05 Mar 2016 10:34

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