Windahl, Ulrika
(2015).
Bacterial infections in dogs with special reference to urinary tract infections, surgical site infections and methicillin-resistant Staphylococcus pseudintermedius.
Diss. (sammanfattning/summary)
Uppsala :
Sveriges lantbruksuniv.,
Acta Universitatis Agriculturae Sueciae, 1652-6880
; 2015:56
ISBN 978-91-576-8310-6
eISBN 978-91-576-8311-3
[Doctoral thesis]
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PDF
674kB |
Abstract
An increase in antimicrobial resistance in canine bacterial pathogens, including multidrug-resistance, has been reported worldwide. Increasing antimicrobial resistance is of concern, not only as it complicates therapy in dogs, but also as it is a public health problem when the pathogens are zoonotic, or the location of resistance genes enables transfer between bacteria of animal and human origin.
The overall aims of this thesis were to gain knowledge of bacterial infections in dogs with special reference to urinary tract infections (UTI), surgical site infections (SSI) and their antimicrobial susceptibility patterns, and of carriage of methicillin-resistant Staphylococcus pseudintermedius (MRSP). The results were intended to aid in choice of antimicrobial treatment of canine UTI and SSI, and in designing recommendations on prevention and control of carriage of MRSP.
First-line antimicrobials were found to be a rational empirical antimicrobial therapy for the studied dog population. In total three percent of detected Escherichia coli isolates were resistant to extended-spectrum cephalosporins. Less than 3% of S. pseudintermedius isolates were methicillin resistant. No methicillin-resistant Staphylococcus aureus (MRSA) isolates were found.
Dogs carried MRSP for several months without clinical signs. Systemic treatment for three weeks or longer with antimicrobials to which the bacterium was resistant was associated with prolonged carriage compared to shorter treatment periods. Three of five dogs treated with an antimicrobial to which the MRSP-isolates were susceptible remained MRSP-carriers. These findings support restricted use of systemic antimicrobial treatment in dogs with possible or confirmed MRSP carriage or infection. The risk of MRSP-colonization in dogs living in a household with an MRSP-infected dog might be lowered if the clinically infected dog (index dog) becomes MRSP -negative. Furthermore, all contact dogs in the family might not carry MRSP continuously during the time the index dog is MRSP-positive. The results of the evaluation of five body sites for MRSP carriage screening suggests that simultaneous sampling of pharynx, perineum and the corner of the mouth, as well as wounds when present, should be recommended. Furthermore, the results suggest that sampling of nostrils is not a priority when screening dogs for MRSP.
Authors/Creators: | Windahl, Ulrika | ||||||||||
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Title: | Bacterial infections in dogs with special reference to urinary tract infections, surgical site infections and methicillin-resistant Staphylococcus pseudintermedius | ||||||||||
Alternative abstract: |
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Series Name/Journal: | Acta Universitatis Agriculturae Sueciae | ||||||||||
Year of publishing : | 2015 | ||||||||||
Depositing date: | 2015 | ||||||||||
Number: | 2015:56 | ||||||||||
Number of Pages: | 90 | ||||||||||
Papers/manuscripts: |
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Place of Publication: | Uppsala | ||||||||||
Publisher: | Department of Clinical Sciences, Swedish University of Agricultural Sciences | ||||||||||
Associated Programs and Other Stakeholders: | SVA - National Veterinary Institute > A contributor is enlisted in SVA | ||||||||||
ISBN for printed version: | 978-91-576-8310-6 | ||||||||||
ISBN for electronic version: | 978-91-576-8311-3 | ||||||||||
ISSN: | 1652-6880 | ||||||||||
Language: | English | ||||||||||
Publication Type: | Doctoral thesis | ||||||||||
Full Text Status: | Public | ||||||||||
Agris subject categories.: | L Animal production > L73 Animal diseases | ||||||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Infectious Medicine (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||||||
Agrovoc terms: | dogs, bacterioses, urinary tract diseases, surgical operations, staphylococcus intermedius, penicillins, resistance to antibiotics, disease control, symptoms, diagnosis, therapy | ||||||||||
Keywords: | bacterial infections, canine, antimicrobial resistance | ||||||||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-2638 | ||||||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2638 | ||||||||||
ID Code: | 12200 | ||||||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||||||
Department: | (VH) > Dept. of Clinical Sciences | ||||||||||
Deposited By: | Ulrika Windahl | ||||||||||
Deposited On: | 11 May 2015 09:36 | ||||||||||
Metadata Last Modified: | 10 Sep 2020 13:41 |
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