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Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications

Galkina, Olga and Ivanov, Vladimir and Agafonov, Alexander and Seisenbaeva, Gulaim and Kessler, Vadim (2015). Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications. Journal of materials chemistry B. 3, 1688-1698
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Official URL: http://dx.doi.org/10.1039/C4TB01823K

Abstract

In this work, new efficient drug delivery systems based on cellulose nanofiber–titania nanocomposites grafted with three different types of model drugs such as diclofenac sodium, penicillamine-D and phosphomycin were successfully synthesized and displayed distinctly different controlled long-term release profiles. Three different methods of medicine introduction were used to show that various interactions between TiO2 and drug molecules could be used to control the kinetics of long-term drug release. All synthesis reactions were carried out in aqueous media. The morphology, chemical structure
and properties of the obtained materials were characterized by SEM, TEM and AFM microscopy, nanoparticle tracking analysis, X-ray diffraction, and TGA analysis. According to FT-IR and UV-Vis spectroscopy data, the titania binds to cellulose nanofibers via formation of ester bonds and to drug molecules via formation of surface complexes. The drug release kinetics was studied in vitro for diclofenac sodium and penicillamine-D spectrophotometrically and for phosphomycin using a radiolabeling analysis with 33P-marked ATP as a model phosphate-anchored biomolecule. The results demonstrated that the obtained nanocomposites could potentially be applied in transdermal drug
delivery for anesthetics, analgesics and antibiotics.

Authors/Creators:Galkina, Olga and Ivanov, Vladimir and Agafonov, Alexander and Seisenbaeva, Gulaim and Kessler, Vadim
Title:Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications
Series/Journal:Journal of materials chemistry B (2050-750X)
Year of publishing :8 January 2015
Depositing date:13 May 2015
Volume:3
Page range:1688-1698
Publisher:Royal Society of Chemistry
ISSN:2050-750X
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Agris subject categories.:X Agricola extesions > X50 Chemistry
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 104 Chemical Sciences > Inorganic Chemistry
(A) Swedish standard research categories 2011 > 2 Engineering and Technology > 210 Nano Technology > Nano Technology
Agrovoc terms:titanium dioxide, drugs, chemistry
Keywords:titania, cross-linking agent, cellulose, drug release, modification
URN:NBN:urn:nbn:se:slu:epsilon-e-2684
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2684
ID Code:12225
Faculty:NL - Faculty of Natural Resources and Agricultural Sciences (until 2013)
Department:(NL, NJ) > Department of Chemistry and Biotechnology (140101-161231)
External funders:Swedish Institute
Deposited By: Ms Olga Galkina
Deposited On:03 Jun 2015 08:35
Metadata Last Modified:04 Mar 2016 13:29
Project info:
Name:Functional hybrid bionanomaterials based on titanium dioxide and cellulose, possessing antibacterial and drug delivery properties
ID:00099/2013
Programme:Visby Programme Scholarships for PhD studies

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