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Predictive markers and risk factors in canine pyometra

Jitpean, Supranee (2015). Predictive markers and risk factors in canine pyometra. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2015:85
ISBN 978-91-576-8368-7
eISBN 978-91-576-8369-4
[Doctoral thesis]

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Abstract

Pyometra is a common and life-threatening disease in intact female dogs, which is generally treated by surgery. Early identification of dogs with high risk of complications or poor prognosis is valuable for optimising treatment and increase survival. The objectives of this thesis were to detect predictive markers for prognosis and outcome of pyometra by investigating clinical and pathophysiological responses and to explore the breed-dependent risk for pyometra and mammary tumours (MTs).

Leucopaenia was the most important predictive variable, associated with an 18-fold increased risk for peritonitis (present in 13% of the dogs) and an over 3.5-fold increased risk for prolonged postoperative hospitalisation. Fever or hypothermia was linked with an increased risk for peritonitis and dogs with moderate to severely depressed general condition or pale mucous membranes had an increased risk for prolonged postoperative hospitalisation. These results show that commonly explored clinical variables may be helpful for predicting prognosis.

Blood concentrations of the acute phase proteins, C-reactive protein and serum amyloid A (SAA) were found to be increased in dogs with pyometra, whereas concentrations of albumin, insulin-like growth factor-I, and iron were decreased. Importantly, SAA concentrations were higher in the dogs that also suffered from sepsis. Though unspecific, SAA could therefore be a potential marker for identifying more severely affected dogs. The neuroendocrine protein chromogranin A was measured by its breakdown products catestatin and vasostatin. Catestatin concentrations were decreased in pyometra whereas vasostatin concentrations did not differ compared to healthy dogs. None of these investigated inflammatory mediators or chromogranin A were useful for outcome prediction as measured by postoperative hospitalisation.

The incidence of pyometra in 110 different breeds was studied using insurance data. Before 10 years of age, 19% of all female dogs had suffered from the disease. Breed greatly affected the risk of both pyometra and MTs.

In summary, these findings show that clinical and laboratory data and analysis of inflammatory variables can be helpful for predicting prognosis and assessing severity in dogs with pyometra. Breed considerably affects the risk of pyometra and MTs, and the information presented in this thesis will be valuable for evaluating possible health benefits of spaying in individual dogs, based on the risk of developing these diseases.

Authors/Creators:Jitpean, Supranee
Title:Predictive markers and risk factors in canine pyometra
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :3 September 2015
Depositing date:3 September 2015
Volume:2015:85
Number of Pages:73
Papers/manuscripts:
NumberReferences
IJitpean S, Holst BS, Emanuelson U, Höglund OV, Pettersson A, Alneryd-Bull C, Hagman R (2014). Outcome of pyometra in female dogs and predictors of peritonitis and prolonged postoperative hospitalization in surgically treated cases. BMC Veterinary Research 10(1):6.
IIJitpean S, Holst BS, Höglund OV, Pettersson A, Olsson U, Strage E, Södersten F, Hagman R (2014). Serum insulin-like growth factor-I, iron, C-reactive protein, and serum amyloid A for prediction of outcome in dogs with pyometra. Theriogenology 82(1):43-48.
IIIJitpean S, Pettersson A, Höglund OV, Holst BS, Olsson U, Hagman R (2014). Increased concentrations of Serum amyloid A in dogs with sepsis caused by pyometra. BMC Veterinary Research 10:9.
IVJitpean S, Stridsberg M, Pettersson A, Höglund OV, Holst BS, Hagman R (2015). Decreased plasma Chromogranin A361-372 (Catestatin) but not Chromogranin A17-38 (Vasostatin) in female dogs with bacterial uterine infection (pyometra). BMC Veterinary Research 11(1):14.
VJitpean S, Hagman R, Holst BS, Höglund OV, Pettersson A, Egenvall A (2012). Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs. Reproduction in Domestic Animals 47:347-350.
Place of Publication:Uppsala
Publisher:Department of Clinical Sciences, Swedish University of Agricultural Sciences
ISBN for printed version:978-91-576-8368-7
ISBN for electronic version:978-91-576-8369-4
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L50 Animal physiology and biochemistry
L Animal production > L73 Animal diseases
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Agrovoc terms:dogs, bitches, pyometra, risk factors, pathogenesis, breeds (animals), leukopenia, proteins, immune response, laboratory diagnosis
Keywords:dog, biomarkers, C-reactive protein, serum amyloid A, insulin like growth factor-I, iron, albumin, SIRS, chromogranin A, catestatin, vasostatin
URN:NBN:urn:nbn:se:slu:epsilon-e-2902
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2902
ID Code:12581
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Fjällveterinärerna and Michael Forsgrens stiftelse and Royal Thai Government Scholarships and Svenska kennelklubben and Thure F och Karin Forsbergs stiftelse
Deposited By: supranee jitpean
Deposited On:03 Sep 2015 14:16
Metadata Last Modified:07 Feb 2016 01:13

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