Söderlund, Robert
(2015).
Molecular epidemiology of verotoxigenic Escherichia coli O157:H7.
Diss. (sammanfattning/summary)
Uppsala :
Sveriges lantbruksuniv.,
Acta Universitatis agriculturae Sueciae, 1652-6880
; 2015:110
ISBN 978-91-576-8418-9
eISBN 978- 91-576-8419-6
[Doctoral thesis]
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PDF
1MB |
Abstract
Verotoxigenic E. coli (VTEC) O157:H7 is a zoonotic disease agent with asymptomatic ruminants such as cattle and sheep as reservoir hosts. Infection in humans can cause bloody diarrhoea with occasionally fatal complications such as haemolytic-uraemic syndrome (HUS), particularly in children. In this thesis, the genetic variation among
representative sets of O157:H7 isolates from Swedish cattle, sheep and human clinical cases is studied to find markers to predict the relative pathogenicity of different
genotypes, and to improve methods for tracing spread of the bacteria. The results show that the same types occur in cattle, sheep and human patients infected within the country. However, certain types are common among ruminants while extremely rare among patient isolates, while others are overrepresented among patients. Better molecular
tracing tools together with interventions targeted against highly pathogenic types of O157:H7 will allow more efficient and cost-effective efforts to reduce the burden of
disease caused by VTEC O157:H7.
| Authors/Creators: | Söderlund, Robert | ||||||||||||
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| Title: | Molecular epidemiology of verotoxigenic Escherichia coli O157:H7 | ||||||||||||
| Series/Journal: | Acta Universitatis agriculturae Sueciae (1652-6880) | ||||||||||||
| Year of publishing : | 2015 | ||||||||||||
| Depositing date: | 7 October 2015 | ||||||||||||
| Volume: | 2015:110 | ||||||||||||
| Number of Pages: | 77 | ||||||||||||
| Papers/manuscripts: |
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| Place of Publication: | Uppsala | ||||||||||||
| Publisher: | Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences | ||||||||||||
| ISBN for printed version: | 978-91-576-8418-9 | ||||||||||||
| ISBN for electronic version: | 978- 91-576-8419-6 | ||||||||||||
| ISSN: | 1652-6880 | ||||||||||||
| Language: | English | ||||||||||||
| Publication Type: | Doctoral thesis | ||||||||||||
| Full Text Status: | Public | ||||||||||||
| Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109) (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Bioinformatics and Systems Biology (methods development to be 10203) (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Cell and Molecular Biology | ||||||||||||
| Agrovoc terms: | dairy cattle, sheep, zoonoses, escherichia coli, bacteria, serotypes, virulence, genes, genetic variation, disease control, epidemiology | ||||||||||||
| Keywords: | Escherichia coli, O157:H7, VTEC, STEC, EHEC, zoonosis, cattle, MLVA | ||||||||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-e-2978 | ||||||||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2978 | ||||||||||||
| ID Code: | 12680 | ||||||||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||||||||
| Department: | (VH) > Dept. of Animal Breeding and Genetics | ||||||||||||
| External funders: | Jordbruksverket / Swedish Board of Agriculture and Myndigheten för samhällsskydd och beredskap / Swedish Civil Contingencies Agency and Stiftelsen Ivar & Elsa Sandbergs Stipendiefond för livsmedelshygienisk forskning | ||||||||||||
| Deposited By: | Robert Söderlund | ||||||||||||
| Deposited On: | 08 Oct 2015 08:57 | ||||||||||||
| Metadata Last Modified: | 06 Nov 2015 21:34 |
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