Hansson, Elisabeth and Skiöldebrand, Eva
(2015).
Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation.
Journal of Inflammation. 12
, 1-11
[Article Review/Survey]
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Available under License Creative Commons Attribution. 1MB |
Official URL: http://dx.doi.org/10.1186/s12950-015-0091-2
Abstract
Several organs in the body comprise cells coupled into networks. These cells have in common that they are excitable but do not express action potentials. Furthermore, they are equipped with Ca2+ signaling systems, which can be intercellular and/or extracellular. The transport of small molecules between the cells occurs through gap junctions comprising connexin 43. Examples of cells coupled into networks include astrocytes, keratinocytes, chondrocytes, synovial fibroblasts, osteoblasts, connective tissue cells, cardiac and corneal fibroblasts, myofibroblasts, hepatocytes, and different types of glandular cells. These cells are targets for inflammation, which can be initiated after injury or in disease. If the inflammation reaches the CNS, it develops into neuroinflammation and can be of importance in the development of systemic chronic inflammation, which can manifest as pain and result in changes in the expression and structure of cellular components. Biochemical parameters of importance for cellular functions are described in this review.
Authors/Creators: | Hansson, Elisabeth and Skiöldebrand, Eva | ||||||
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Title: | Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation | ||||||
Series Name/Journal: | Journal of Inflammation | ||||||
Year of publishing : | 25 July 2015 | ||||||
Depositing date: | 12 October 2015 | ||||||
Volume: | 12 | ||||||
Page range: | 1-11 | ||||||
Number of Pages: | 11 | ||||||
Publisher: | BioMed Central | ||||||
ISSN: | 1476-9255 | ||||||
Language: | English | ||||||
Publication Type: | Article Review/Survey | ||||||
Refereed: | Yes | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Agris subject categories.: | X Agricola extesions > X38 Human medicine, health, and safety | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Medicinal Chemistry | ||||||
Agrovoc terms: | cells, inflammation, pain, chronic course | ||||||
Keywords: | Coupled cell networks, Inflammation, Pain spreading, Ca2+ signaling, Connexin 43, Gap junctions | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-2986 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2986 | ||||||
Additional ID: |
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ID Code: | 12687 | ||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
Department: | (VH) > Dept. of Biomedical Sciences and Veterinary Public Health | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 13 Oct 2015 07:52 | ||||||
Metadata Last Modified: | 09 Sep 2020 14:17 |
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