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Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation

Hansson, Elisabeth and Skiöldebrand, Eva (2015). Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation. Journal of Inflammation. 12, 1-11
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Official URL: http://dx.doi.org/10.1186/s12950-015-0091-2

Abstract

Several organs in the body comprise cells coupled into networks. These cells have in common that they are excitable but do not express action potentials. Furthermore, they are equipped with Ca2+ signaling systems, which can be intercellular and/or extracellular. The transport of small molecules between the cells occurs through gap junctions comprising connexin 43. Examples of cells coupled into networks include astrocytes, keratinocytes, chondrocytes, synovial fibroblasts, osteoblasts, connective tissue cells, cardiac and corneal fibroblasts, myofibroblasts, hepatocytes, and different types of glandular cells. These cells are targets for inflammation, which can be initiated after injury or in disease. If the inflammation reaches the CNS, it develops into neuroinflammation and can be of importance in the development of systemic chronic inflammation, which can manifest as pain and result in changes in the expression and structure of cellular components. Biochemical parameters of importance for cellular functions are described in this review.

Authors/Creators:Hansson, Elisabeth and Skiöldebrand, Eva
Title:Coupled cell networks are target cells of inflammation, which can spread between different body organs and develop into systemic chronic inflammation
Series/Journal:Journal of Inflammation (1476-9255)
Year of publishing :25 July 2015
Depositing date:12 October 2015
Volume:12
Page range:1-11
Number of Pages:11
Publisher:BioMed Central
ISSN:1476-9255
Language:English
Publication Type:Article Review/Survey
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:X Agricola extesions > X38 Human medicine, health, and safety
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Medicinal Chemistry
Agrovoc terms:cells, inflammation, pain, chronic course
Keywords:Coupled cell networks, Inflammation, Pain spreading, Ca2+ signaling, Connexin 43, Gap junctions
URN:NBN:urn:nbn:se:slu:epsilon-e-2986
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-2986
Additional ID:
Type of IDID
Web of Science (WoS)000358486900001
DOI10.1186/s12950-015-0091-2
ID Code:12687
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:13 Oct 2015 07:52
Metadata Last Modified:04 Mar 2016 16:42

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