aspects on aetiology and pathology
Larsson, Jenny
(2016).
Neonatal porcine diarrhoea.
Diss. (sammanfattning/summary)
Uppsala :
Sveriges lantbruksuniv.,
Acta Universitatis Agriculturae Sueciae, 1652-6880
; 2016:13
ISBN 978-91-576-8528-5
eISBN 978-91-576-8529-2
[Doctoral thesis]
![]() |
PDF
2MB |
Abstract
Diarrhoea in newborn piglets is an old but still relevant problem in pig production globally. During the last decades, reports from a number of countries describe problems with neonatal porcine diarrhoea (NPD) despite the use of previously effective preventive measures. The aim of this thesis was to investigate and characterise the problem with NPD in Swedish piglet-producing herds. The magnitude of the problem was estimated by a questionnaire study distributed to 170 randomly selected herds. A response rate of 58% was achieved. The total herd-level prevalence of NPD, including herds with sporadic cases, was 79.6%, indicating that NPD is a substantial problem. Ten herds affected by NPD were selected for in-depth studies on the potential causes of the diarrhoea. From each herd, five diarrhoeic and two healthy control piglets were selected. The piglets were blood-sampled for analysis of serum ɣ-globulin, and thereafter euthanized and necropsied. The intestines were sampled for histopathology, virology, and bacteriology. There was no difference in serum ɣ-globulin concentration between diarrhoeic and non-diarrhoeic piglets and pathological lesions in the intestines were generally mild. Porcine enterotoxigenic Escherichia (E.) coli was only found in two piglets. Further, extended virulence gene profiling did not suggest involvement of other diarrhoeagenic pathotypes of E. coli. Clostridium (C.) perfringens type C was not detected, and neither C. perfringens type A nor C. difficile could be related to the diarrhoea. Furthermore, no protozoa such as Cystoisospora suis were observed in the intestinal mucosa. By viral metagenomics analyses of intestinal samples, the only previously well-established porcine enteropathogen found was rotavirus that was present in two herds. Otherwise, the data did not suggest involvement of previously known viruses. The only consistent finding associated with diarrhoea was small intestinal colonisation by Enterococcus (E.) hirae. Enteroadherent E. hirae was detected in 60% of the diarrhoeic piglets from six of the herds and was associated with small intestinal mucosal lesions in more than 50% of the cases (10/18). Thus, our results show that diarrhoea in newborn piglets may have other causes than the well-established pathogens previously associated with NPD and a potential involvement of E. hirae is suggested.
Authors/Creators: | Larsson, Jenny | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Title: | Neonatal porcine diarrhoea | ||||||||||
Subtitle: | aspects on aetiology and pathology | ||||||||||
Series/Journal: | Acta Universitatis Agriculturae Sueciae (1652-6880) | ||||||||||
Year of publishing : | 2016 | ||||||||||
Depositing date: | 2016 | ||||||||||
Number: | 2016:13 | ||||||||||
Number of Pages: | 96 | ||||||||||
Papers/manuscripts: |
| ||||||||||
Place of Publication: | Uppsala | ||||||||||
Publisher: | Department of Clinical Sciences, Swedish University of Agricultural Sciences | ||||||||||
ISBN for printed version: | 978-91-576-8528-5 | ||||||||||
ISBN for electronic version: | 978-91-576-8529-2 | ||||||||||
ISSN: | 1652-6880 | ||||||||||
Language: | English | ||||||||||
Additional Information: | Name of the project: Spädgrisdiarré - ett nygammalt och allvarligt problem i moderna grisbesättningar | ||||||||||
Publication Type: | Doctoral thesis | ||||||||||
Full Text Status: | Public | ||||||||||
Agris subject categories.: | L Animal production > L73 Animal diseases | ||||||||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology | ||||||||||
Agrovoc terms: | swine, piglets, newborn animals, diarrhoea, enterococcus hirae, escherichia coli, clostridium perfringens, clostridium difficile, rotavirus, aetiology, pathology | ||||||||||
Keywords: | Enterococcus hirae, Escherichia coli, ETEC, Clostridium perfringens, Clostridium difficile, rotavirus, viral metagenomics, neonate, pig, swine, NNPD | ||||||||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-3200 | ||||||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-3200 | ||||||||||
ID Code: | 13024 | ||||||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||||||
Department: | (VH) > Dept. of Clinical Sciences | ||||||||||
External funders: | Stiftelsen Lantbruksforskning | ||||||||||
Deposited By: | Jenny Larsson | ||||||||||
Deposited On: | 08 Feb 2016 08:00 | ||||||||||
Metadata Last Modified: | 10 Sep 2020 13:41 |
Repository Staff Only: item control page