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Extended Spectrum Beta-Lactamase/AmpC-Producing E Coli in Dogs Treated with Antimicrobials in Surgical Wards

Östberg, Sofia and Börjesson, Stefan and Trowald-Wigh, Gunilla and Fernström, Lise-Lotte and Nicol, Claire and Bergström, Annika (2015). Extended Spectrum Beta-Lactamase/AmpC-Producing E Coli in Dogs Treated with Antimicrobials in Surgical Wards. International journal of applied research in veterinary medicine. 13:1, 80-88
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Abstract

The aim of this study is to investigate the prevalence and carriage of Extended Spec - trum Beta-Lactamase (ESBL) and AmpC- producing strains of E. coli and Klebsi - ella spp in hospitalized dogs treated with antimicrobials. Tissue and fecal samples from 66 dogs were analyzed for presence of AmpC or ESBL producing bacteria. The dogs had to have been admitted to the surgical ward for at least 24 hours and have received antimicrobial treatment. Samples were plated onto bovine blood agar and after incubation for 24 + 24 h, five colonies morphologically consistent with E.coli and Klebsiella spp , were selected and recultured onto media containing antimicrobials. Dogs carrying ESBL/AmpC- producing bacteria were retested for rectal colonisation at 3-6 months intervals for up to 16 months. Five (7.6%) dogs carried bacterial strains posi - tive for ESBL/AmpC- producing- genes in feces. All tissue samples were negative. One dog, previously positive for bla CMY-2 , carried ESBL genotype bla TEM-52 , in the second sample. Four dogs remained posi - tive throughout the testing. None of the dogs had signs of infection or symptoms associ - ated with the carriage of ESBL or plasmid mediated-AmpC- producing bacteria. Seven unique MLVA-types were identified. The results from this study show fecal car - riage for as long as 16 months of ESBL/ AmpC- producing E.coli in dogs treated with antimicrobials. Although clonal spread could not be verified in this study, the risk of dissemination of multiresistant bacteria in animal hospitals and in the community must be considered.

Authors/Creators:Östberg, Sofia and Börjesson, Stefan and Trowald-Wigh, Gunilla and Fernström, Lise-Lotte and Nicol, Claire and Bergström, Annika
Title:Extended Spectrum Beta-Lactamase/AmpC-Producing E Coli in Dogs Treated with Antimicrobials in Surgical Wards
Series/Journal:International journal of applied research in veterinary medicine (1559-470X)
Year of publishing :2015
Volume:13
Number:1
Page range:80-88
Number of Pages:9
Publisher:Veterinary Solutions LLC
ISSN:1559-470X
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:L Animal production > L70 Veterinary science and hygiene - General aspects
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 304 Medical Biotechnology > Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Keywords:ESBL, AmpC, antimicrobial resistance, dogs
URN:NBN:urn:nbn:se:slu:epsilon-e-3517
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-3517
Additional ID:
Type of IDID
Web of Science (WoS)000370867600009
ID Code:13370
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
University Animal Hospital (UAH)
Deposited By: SLUpub Connector
Deposited On:21 Jun 2016 09:42
Metadata Last Modified:21 Jun 2016 09:42

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