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Metabolomics study of cereal grains reveals the discriminative metabolic markers associated with anatomical compartments

Coulomb, Marie and Gombert, Antonin and Moazzami, Ali (2015). Metabolomics study of cereal grains reveals the discriminative metabolic markers associated with anatomical compartments. Italian journal of food science. 27:2, 142-150
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Abstract

This study used NMR-based metabolomics to compare the metabolic profile of different anatomical compartments of cereal grains i.e. bran and endosperm in order to gain further insights into their possible role in the beneficial health effects of whole grain products (WG). Polar water-soluble metabolites in 64 bran and endosperm, samples from rye and wheat were observed using 600 MHz NMR. Bran samples had higher contents of 12 metabolites than endosperm samples. A comparative approach revealed higher contents of azelaic acid and sebacic acid in bran than in endosperm. In a pilot study, the consumption of WG rye bread (485 g) caused NMR signals in 24h urine corresponding to azelaic acid. The relatively high abundance, anatomical specificity, pattern of metabolism, urinary excretion in human, antibacterial, and anticancer activities suggest further studying of azelaic acid when exposure to WG or beneficial effects of WG are investigated.

Authors/Creators:Coulomb, Marie and Gombert, Antonin and Moazzami, Ali
Title:Metabolomics study of cereal grains reveals the discriminative metabolic markers associated with anatomical compartments
Series/Journal:Italian journal of food science (BIB11338567)
Year of publishing :2015
Volume:27
Number:2
Page range:142-150
Number of Pages:9
Publisher:Chiriotti Editori
ISSN:1120-1770
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:Q Food science > Q01 Food science and technology
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Food Science
Keywords:metabolomics, NMR, wholegrain, rye, wheat, metabolites, biomarkers
URN:NBN:urn:nbn:se:slu:epsilon-e-3518
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-3518
Additional ID:
Type of IDID
Web of Science (WoS)000361638800003
ID Code:13380
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Food Science (until 161231)
Deposited By: SLUpub Connector
Deposited On:21 Jun 2016 09:48
Metadata Last Modified:21 Jun 2016 09:48

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