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Genome wide binding site analysis reveals transcriptional coactivation of cytokinin-responsive genes by DELLA proteins

Marín-de la Rosa, Nora and Pfeiffer, Anne and Hill, Kristine and Locascio, Antonella and Bhalerao, Rupali R. and Miskolczi, Pal Csaba and Grønlund, Anne L. and Wanchoo-Kohl, Aakriti and Stephan G., Thomas and Bennett, Malcom J. and Lohmann, Jan U. and Blázquez, Miguel A. and Alabadí, David (2015). Genome wide binding site analysis reveals transcriptional coactivation of cytokinin-responsive genes by DELLA proteins. PLoS genetics. 11:7, 1-20
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Official URL: http://dx.doi.org/10.1371/journal.pgen.1005337

Abstract

The ability of plants to provide a plastic response to environmental cues relies on the connectivity between signaling pathways. DELLA proteins act as hubs that relay environmental information to the multiple transcriptional circuits that control growth and development through physical interaction with transcription factors from different families. We have analyzed the presence of one DELLA protein at the Arabidopsis genome by chromatin immunoprecipitation coupled to large-scale sequencing and we find that it binds at the promoters of multiple genes. Enrichment analysis shows a strong preference for cis elements recognized by specific transcription factor families. In particular, we demonstrate that DELLA proteins are recruited by type-B ARABIDOPSIS RESPONSE REGULATORS (ARR) to the promoters of cytokinin-regulated genes, where they act as transcriptional co-activators. The biological relevance of this mechanism is underpinned by the necessity of simultaneous presence of DELLAs and ARRs to restrict root meristem growth and to promote photomorphogenesis.

Authors/Creators:Marín-de la Rosa, Nora and Pfeiffer, Anne and Hill, Kristine and Locascio, Antonella and Bhalerao, Rupali R. and Miskolczi, Pal Csaba and Grønlund, Anne L. and Wanchoo-Kohl, Aakriti and Stephan G., Thomas and Bennett, Malcom J. and Lohmann, Jan U. and Blázquez, Miguel A. and Alabadí, David
Title:Genome wide binding site analysis reveals transcriptional coactivation of cytokinin-responsive genes by DELLA proteins
Series/Journal:PLoS genetics (1553-7404)
Year of publishing :2015
Volume:11
Number:7
Page range:1-20
Number of Pages:20
Publisher:Public Library of Science
ISSN:1553-7404
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:F Plant production > F30 Plant genetics and breeding
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
Agrovoc terms:genomes, protiens, plants
Keywords:genomes, protiens, plants
URN:NBN:urn:nbn:se:slu:epsilon-e-3609
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-3609
Additional ID:
Type of IDID
Web of Science (WoS)000360622200016
ID Code:13574
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Forest Genetics and Plant Physiology
Deposited By: SLUpub Connector
Deposited On:19 Aug 2016 07:00
Metadata Last Modified:19 Aug 2016 07:00

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