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Studies on verotoxigenic Escherichia coli O157 in Swedish cattle

from sampling to disease spread modelling

Widgren, Stefan (2016). Studies on verotoxigenic Escherichia coli O157 in Swedish cattle. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2016:122
ISBN 978-91-576-8747-0
eISBN 978-91-576-8748-7
[Doctoral thesis]

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Abstract

Verotoxigenic Escherichia coli O157:H7 (VTEC O157) is an important zoonotic pathogen capable of causing infections in humans, sometimes with severe symptoms such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). Cattle are considered to be the main reservoir of the bacterium. In this thesis, sampling strategies to detect VTEC O157 in a cattle herd, risk factors for the introduction and the spread of VTEC O157 in Swedish cattle herds, as well as options for control, are studied. A spatial data-driven stochastic model was developed to explore the spread of VTEC O157 by livestock movements and local transmission among proximal holdings in the complete Swedish cattle population. Overshoe sampling alone or in combination with dust and/or pooled pat sampling were established to be reliable for identifying cattle herds with animals shedding VTEC O157. Results from field studies and computer simulations show that animal movements and local spread are important for the transmission of VTEC O157 in the Swedish cattle population. However, simulated control measures based on reducing the between-herd VTEC O157 transmission by animal movements and local spread, had marginal effect in decreasing the prevalence. On the other hand, simulated control measures based on reducing the shedding and susceptibility, efficiently decreased the prevalence of VTEC O157 in the Swedish cattle population.

Authors/Creators:Widgren, Stefan
Title:Studies on verotoxigenic Escherichia coli O157 in Swedish cattle
Subtitle:from sampling to disease spread modelling
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :2016
Volume:2016:122
Number of Pages:62
Papers/manuscripts:
NumberReferences
IWidgren S, Eriksson E, Aspán A, Emanuelson U, Alenius S, Lindberg A (2013). Environmental sampling for evaluating verotoxigenic Escherichia coli O157:H7 status in dairy cattle herds. Journal of Veterinary Diagnostic Investigation 25(2), 189–198. doi:10.1177/1040638712474814
IIWidgren S, Söderlund R, Eriksson E, Fasth C, Aspán A, Emanuelson U, Alenius S, Lindberg A (2015). Longitudinal observational study over 38 months of verotoxigenic Escherichia coli O157:H7 status in 126 cattle herds. Preventive Veterinary Medicine 121(3–4), 343–352. doi:10.1016/j.prevetmed.2015.08.010
IIIWidgren S, Engblom S, Bauer P, Frössling J, Emanuelson U, Lindberg A (2016). Data-driven network modeling of disease transmission using complete population movement data: Spread of VTEC O157 in Swedish cattle. Veterinary Research 47:81. doi:10.1186/s13567-016-0366-5
IVWidgren S, Engblom S, Emanuelson U, Lindberg A (2016). Spatiotemporal modelling of verotoxigenic Escherichia coli O157 in cattle in Sweden: Exploring options for control. (manuscript)
Place of Publication:Uppsala
Publisher:Department of Clinical Sciences, Swedish University of Agricultural Sciences
ISBN for printed version:978-91-576-8747-0
ISBN for electronic version:978-91-576-8748-7
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
U Auxiliary disciplines > U10 Mathematical and statistical methods
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 101 Mathematics > 10105 Computational Mathematics
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Other Veterinary Science
Agrovoc terms:escherichia coli, zoonoses, cattle, herds, epidemiology, data analysis, mathematical models, simulation, disease control, sweden
Keywords:Data-driven disease spread modelling, Computer simulations, Epidemiology, VTEC O157, Control, Zoonosis
URN:NBN:urn:nbn:se:slu:epsilon-e-3764
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-3764
ID Code:13821
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Jordbruksverket / Swedish Board of Agriculture and Stiftelsen Lantbruksforskning
Deposited By: Stefan Widgren
Deposited On:07 Nov 2016 13:59
Metadata Last Modified:26 Jul 2017 15:36

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