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Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs

Höglund, Katja and Lequarré, A-S. and Bersås Ljungvall, Ingrid and Merveille, A-C. and Wiberg, M. and Hanås, Sofia and Gouni, V and Lundgren Willesen, J. and Mejer Sørensen, L. and Wess, Gerhard and Tiret, L. and Kierczak, Marcin and Forsberg, Simon and Seppälä, E. and Lindblad-Toh, K. and Lohi, Hannes and Chetboul, Valerie and Fredholm, Merete and Häggström, Jens (2016). Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs. Journal of veterinary internal medicine. 30:2, 566-573
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Official URL: http://dx.doi.org/10.1111/jvim.13829

Abstract

Background: There are breed differences in several blood variables in healthy dogs.
Objective: Investigate breed variation in plasma endothelin-1 (ET-1) concentration, plasma renin activity, and serum cortisol concentration.
Animals: Five-hundred and thirty-one healthy dogs of 9 breeds examined at 5 centers (2-4 breeds/center).
Methods: Prospective observational study. Circulating concentrations of ET-1 and cortisol, and renin activity, were measured using commercially available assays. Absence of organ-related or systemic disease was ensured by thorough clinical investigations, including blood pressure measurement, echocardiography, ECG, blood and urine analysis.
Results: Median ET-1 concentration was 1.29 (interquartile range [IQR], 0.97-1.82) pg/mL, median cortisol concentration 46.0 (IQR, 29.0-80.8) nmol/L, and median renin activity 0.73 (IQR, 0.48-1.10) ng/mL/h in all dogs. Overall, breed differences were found in ET-1 and cortisol concentrations, and renin activity (P < .0001 for all). Pair-wise comparisons between breeds differed in 67% of comparisons for ET-1, 22% for cortisol, and 19% for renin activity, respectively. Within centers, breed differences were found at 5/5 centers for ET-1, 4/5 centers for cortisol, and 2/5 centers for renin activity. Newfoundlands had highest median ET-1 concentration, 3 times higher than Cavalier King Charles Spaniels, Doberman Pinschers, and Dachshunds. Median renin activity was highest in Dachshunds, twice the median value in Newfoundlands and Boxers. Median cortisol concentration was highest in Finnish Lapphunds, almost 3 times higher than in Boxers.
Conclusions and Clinical Importance: Breed variation might be important to take into consideration when interpreting test results in clinical studies.

Authors/Creators:Höglund, Katja and Lequarré, A-S. and Bersås Ljungvall, Ingrid and Merveille, A-C. and Wiberg, M. and Hanås, Sofia and Gouni, V and Lundgren Willesen, J. and Mejer Sørensen, L. and Wess, Gerhard and Tiret, L. and Kierczak, Marcin and Forsberg, Simon and Seppälä, E. and Lindblad-Toh, K. and Lohi, Hannes and Chetboul, Valerie and Fredholm, Merete and Häggström, Jens
Title:Effect of Breed on Plasma Endothelin-1 Concentration, Plasma Renin Activity, and Serum Cortisol Concentration in Healthy Dogs
Series/Journal:Journal of veterinary internal medicine (0891-6640)
Year of publishing :2016
Volume:30
Number:2
Page range:566-573
Number of Pages:8
Publisher:Wiley Periodicals, Inc
ISSN:0891-6640
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Cardiac and Cardiovascular Systems
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Agrovoc terms:breeds (animals), dogs, blood composition
Keywords:Biomarkers, Breed variation, Canines, Vasoactive
URN:NBN:urn:nbn:se:slu:epsilon-e-4004
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4004
Additional ID:
Type of IDID
Web of Science (WoS)000372981500010
DOI10.1111/jvim.13829
ID Code:14139
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Anatomy, Physiology and Biochemistry
External funders:EU FP7
Deposited By: SLUpub Connector
Deposited On:07 Mar 2017 13:03
Metadata Last Modified:07 Mar 2017 13:03

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