Srithunyarat, Thanikul and Höglund, Odd and Hagman, Ragnvi and Stridsberg, Mats and Olsson, Ulf and Lagerstedt, Anne-Sofie and Pettersson, Ann
(2016).
Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy.
BMC Research Notes. 9
, 1-9
[Journal article]
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Official URL: http://dx.doi.org/10.1186/s13104-016-2193-1
Abstract
Background: The stress reaction induced by surgery and associated pain may be detrimental for patient recovery and should be minimized. The neuropeptide chromogranin A (CGA) has shown promise as a sensitive biomarker for stress in humans. Little is known about CGA and its derived peptides, catestatin (CST) and vasostatin (VS), in dogs undergoing surgery. The objectives of this study were to investigate and compare concentrations of CGA epitopes CST and VS, cortisol, body temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF) and visual analog scales (VAS) for stress and pain behavior in dogs before and after ovariohysterectomy.
Methods: Thirty healthy privately owned female dogs admitted for elective ovariohysterectomy were included. Physical examination, CMPS-SF, pain behavior VAS, and stress behavior VAS were recorded and saliva and blood samples were collected before surgery, 3h after extubation, and once at recall 7–15 days after surgery. Dogs were premedicated with morphine and received carprofen as analgesia for 7 days during the postoperative period.
Results: At 3h after extubation, CMPS-SF and pain behavior VAS scores had increased (p<0.0001) and stress behavior VAS scores, temperature, respiratory rate (p<0.0001), plasma CST concentrations (p=0.002) had decreased significantly compared to before surgery. No significant differences were observed in the subjective and physiological parameters between before surgery and at recall, but plasma CST (p=0.04) and serum cortisol (p=0.009) were significantly lower at recall. Plasma VS, saliva CST, and heart rate did not differ significantly at any observed time.
Conclusion: Study parameters for evaluating surgery-induced stress and pain changed in dogs subjected to ovariohysterectomy. To further evaluate CST and VS usefulness as pain biomarkers, studies on dogs in acute painful situations are warranted.
Authors/Creators: | Srithunyarat, Thanikul and Höglund, Odd and Hagman, Ragnvi and Stridsberg, Mats and Olsson, Ulf and Lagerstedt, Anne-Sofie and Pettersson, Ann |
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Title: | Catestatin, vasostatin, cortisol, temperature, heart rate, respiratory rate, scores of the short form of the Glasgow composite measure pain scale and visual analog scale for stress and pain behavior in dogs before and after ovariohysterectomy |
Series/Journal: | BMC Research Notes (1756-0500) |
Year of publishing : | 2016 |
Volume: | 9 |
Page range: | 1-9 |
Number of Pages: | 9 |
Publisher: | BioMed Central |
ISSN: | 1756-0500 |
Language: | English |
Publication Type: | Journal article |
Refereed: | Yes |
Article category: | Scientific peer reviewed |
Version: | Published version |
Copyright: | Creative Commons: Attribution 4.0 |
Full Text Status: | Public |
Agris subject categories.: | L Animal production > L70 Veterinary science and hygiene - General aspects |
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science |
Agrovoc terms: | Canis, veterinary medicine, pain |
Keywords: | Catestatin, Chromogranin A, Cortisol, Dogs, Ovariohysterectomy, Pain, Short form of the Glasgow composite measure pain scale, Stress, Vasostatin, Visual analog scale |
URN:NBN: | urn:nbn:se:slu:epsilon-e-4099 |
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4099 |
ID Code: | 14223 |
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science |
Department: | (VH) > Dept. of Clinical Sciences |
Deposited By: | SLUpub Connector |
Deposited On: | 11 Apr 2017 07:12 |
Metadata Last Modified: | 25 Sep 2020 22:51 |
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