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Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting

Hedenqvist, Patricia and Trbakovic, Amela and Thor, Andreas and Ley, Cecilia and Ekman, Stina and Jensen Waern, Marianne (2016). Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting. Research in veterinary science. 107, 123-131
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Official URL: http://dx.doi.org/10.1016/j.rvsc.2016.05.010

Abstract

In connection with bilateral maxillary sinus augmentation, the acute effects of the nonsteroidal anti-inflammatory drug carprofen on facial expressions and long-term effects on bone formation were evaluated in 18 male New Zealand White rabbits. A 10 × 10mm bone window was drilled in the maxilla, the sinus membrane elevated and a titanium mini-implant inserted. One of two test materials was randomly inserted unilaterally and bovine bone chips (control) on the contralateral side in the created space. Rabbits were randomly allocated to receive buprenorphine plus carprofen (n = 9) or buprenorphine plus saline (n = 9) postoperatively. Buprenorphine was administered subcutaneously every 6 h for 3 days in a tapered dose (0.05-0.01 mg/kg) and carprofen (5 mg/kg) or saline administered subcutaneously 1 h before, and daily for 4 days postoperatively. To assess pain, clinical examination, body weight recording and scoring of facial expressions from photos taken before, and 6-13 h after surgery were performed. Twelve weeks after surgery the rabbits were euthanized and sections of maxillary bones and sinuses were analysed with histomorphometry and by qualitative histology. Carprofen had no effect on mean facial expression scores,which increased from 0.0 to 3.6 (carprofen) and 4.3 (saline), of a maximum of 8.0. Neither did carprofen have an effect on bone formation or implant incorporation, whereas the test materials had. In conclusion, treatment with 5mg/kg carprofen once daily for 5 days did not reduce facial expression scores after maxillary sinus augmentation in buprenorphine treated rabbits and did not affect long term bone formation.

Authors/Creators:Hedenqvist, Patricia and Trbakovic, Amela and Thor, Andreas and Ley, Cecilia and Ekman, Stina and Jensen Waern, Marianne
Title:Carprofen neither reduces postoperative facial expression scores in rabbits treated with buprenorphine nor alters long term bone formation after maxillary sinus grafting
Series/Journal:Research in veterinary science (0034-5288)
Year of publishing :2016
Volume:107
Page range:123-131
Number of Pages:9
Publisher:Elsevier
ISSN:0034-5288
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 305 Other Medical Sciences > Other Medical Sciences not elsewhere specified
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Other Veterinary Science
Agrovoc terms:bone formation, pain, rabbits
Keywords:Bone formation, Pain, NSAID, Implant, Sinus-lift, Experimental animal, rabbits
URN:NBN:urn:nbn:se:slu:epsilon-e-4173
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4173
Additional ID:
Type of IDID
Web of Science (WoS)000381541600019
DOI10.1016/j.rvsc.2016.05.010
ID Code:14246
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:18 May 2017 06:17
Metadata Last Modified:27 May 2017 23:15

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