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Endemic aleutian disease

a strategy for diagnosis and control

Andersson, Anna-Maria (2017). Endemic aleutian disease. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2017:38
ISBN 978-91-576-8849-1
eISBN 978-91-576-8850-7
[Doctoral thesis]

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Abstract

Aleutian disease (AD) is a common global disease in farmed mink caused by infection with Aleutian disease virus (ADV). This thesis investigated the use of ADV antibody ELISA as a tool to reduce the impact on welfare and reproduction of mink in ADV endemic areas. First, two ELISA systems were compared. The ELISA system based on VP2 antigen detected ADV antibodies in serum with high sensitivity and specificity when compared to counter immunoelectrophoresis (CIEP). In contrast, the ELISA system based on ADV-G antigen did not perform as well and had a low sensitivity
compared to CIEP. The VP2 ELISA also detected antibodies to ADV in dried whole blood eluted from filter paper (DBS) with a preserved high sensitivity and specificity and
with good correlation to antibody levels in serum. The ADV antibody levels were comparable over a period of two weeks which may correspond to the time needed to sample all mink in large herds.

The correlation between the estimated antibody level in DBS and the ratio of albumin: gamma globulins (A:γG) in serum in individual mink was generally high but superior for
DBS compared to serum samples from the same mink. The use of DBS VP2 ELISA was therefore concluded to be the preferable indirect method for estimating hypergammaglobulinemia in mink. Further, the association between the reproductive performance and the antibody level was also investigated at an individual level. For the
primiparous mink, the risk of being barren was associated with the AD status prior to mating. Diseased mink had a higher risk of being barren than non-diseased mink. In
addition, the litter size of the primiparous non-barren female mink was also associated with the AD status prior to mating, where diseased mink had a 5% reduced litter size.
For older mink, on the other hand, no difference due to AD status was found but they had approximately 5 % larger litters than primiparous mink irrespective of AD status.

To aid selection of future breeders, the female mink could be categorized into two or three different disease categories depending on the mean antibody level in the herd.
Selection of healthy mink for breeding can be expected to be beneficial for the welfare of the female mink, the overall breeding performance of the herd, as well as the
production economy.

Authors/Creators:Andersson, Anna-Maria
Title:Endemic aleutian disease
Subtitle:a strategy for diagnosis and control
Series/Journal:Acta Universitatis agriculturae Sueciae (1652-6880)
Year of publishing :2017
Depositing date:19 April 2017
Volume:2017:38
Number of Pages:96
Papers/manuscripts:
NumberReferences
IAndersson, AM.* and Wallgren, P. (2013). Evaluation of two enzymelinked immunosorbent assays for serodiagnosis of Aleutian mink disease virus infection in mink. Acta Veterinaria Scandinavica, 55(1): 86.
IIAndersson AM.*, Reineck HB., Nyman AK., and Wallgren P. (2015). Quantitative detection of antibodies to Aleutian disease virus in dried blood spots as an estimation of hypergammaglobulinemia in mink. Virology & Mycology 4: 147
IIIAndersson, AM.*, Nyman AK., and Wallgren, P. (2016). Serodiagnosis of Aleutian disease virus infection in mink – Short term stability and long term consistency of antibody levels measured by VP2 ELISA. Veterinary Sciences: Research and Reviews, 2(1): pp. 23-30
IVAndersson, AM.*, Nyman AK., and Wallgren, P. (2017) A retrospective cohort study estimating the individual Aleutian disease progress in female mink using a VP2 ELISA and its association to reproductive performance. Preventive Veterinary Medicine, 140C: pp. 60-66
Place of Publication:Uppsala
Publisher:Department of Clinical Sciences, Swedish University of Agricultural Sciences
Associated Programs and Other Stakeholders:SVA - National Veterinary Institute > A contributor is enlisted in SVA
ISBN for printed version:978-91-576-8849-1
ISBN for electronic version:978-91-576-8850-7
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L10 Animal genetics and breeding
L Animal production > L73 Animal diseases
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Other Veterinary Science
Agrovoc terms:minks, aleutioan disease, antibody formation, gammaglobulins, reproduction, animal welfare, animal breeding, reproductive performance
Keywords:Aleutian disease, Plasmacytosis, ADV, mink, CIEP, counter immunoelectrophoresis, ELISA, hypergammaglobulinemia, breeding result, reproduction, litter size, barren percentage
URN:NBN:urn:nbn:se:slu:epsilon-e-4113
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4113
ID Code:14254
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
External funders:Magnus Bergvalls stiftelse
Deposited By: Anna-Maria / A-M Andersson
Deposited On:21 Apr 2017 07:54
Metadata Last Modified:21 Apr 2017 07:54

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