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Diagnostic possibilities from a serum sample - Clinical value of new methods within small animal reproduction, with focus on anti-Mullerian hormone

Ström Holst, Bodil (2017). Diagnostic possibilities from a serum sample - Clinical value of new methods within small animal reproduction, with focus on anti-Mullerian hormone. Reproduction in domestic animals. 52:Suppl. 2, 303-309
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Official URL: http://dx.doi.org/10.1111/rda.12856

Abstract

During the last decade, analysis of anti-Mullerian hormone (AMH), highly conserved between mammalian species, has contributed to new information in reproductive endocrinology, due to clinically available diagnostic assays. AMH is produced solely in the gonads, in the Sertoli cells of testes and granulosa cells of the ovary, and thus offers possibilities to diagnose physiologic and pathologic conditions involving these organs. This article reviews indications for AMH analysis in cats and dogs, including diagnosing the presence of gonads, and granulosa or Sertoli cell tumours. Diagnostic challenges are addressed. One specific organ, the prostate, is commonly affected by pathologic changes in older dogs. A commercial assay for analysing canine prostatic specific esterase (CPSE) enables analysis of CPSE in clinical practice, of potential value in the workup of benign prostatic hyperplasia in male dogs. This is described in this review, as is a new method for analysis of steroids: liquid chromatography-tandem mass spectrometry LC-MS/MS. Steroids have since long been analysed in studies on reproduction, and LC-MS/MS has the advantage of allowing analysis of panels of multiple steroids from small sample volumes. Altogether, these available methods may give new insights into small animal reproduction and are valuable tools for the practicing veterinarian.

Authors/Creators:Ström Holst, Bodil
Title:Diagnostic possibilities from a serum sample - Clinical value of new methods within small animal reproduction, with focus on anti-Mullerian hormone
Series/Journal:Reproduction in domestic animals (1439-0531)
Year of publishing :2017
Volume:52
Number:Suppl. 2
Page range:303-309
Number of Pages:7
Publisher:Wiley
ISSN:1439-0531
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Agrovoc terms:castration, hormones, reproduction
Keywords:AMH, BPH, castration, LC-MS, MS
URN:NBN:urn:nbn:se:slu:epsilon-e-4177
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4177
Additional ID:
Type of IDID
DOI10.1111/rda.12856
Web of Science (WoS)000399379200052
ID Code:14337
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:22 May 2017 09:57
Metadata Last Modified:19 Oct 2017 23:15

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