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Experimentally induced swine dysentery

with special reference to alterations in Lymphocyte sub-populations, cytokines and amino acids in blood

Jonasson-Kruse, Robert (2007). Experimentally induced swine dysentery. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis Agriculturae Sueciae, 1652-6880 ; 2007:16
ISBN 978-91-576-7315-2
[Doctoral thesis]

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Swine dysentery is an enteric disease that is present in most pig-producing countries. It is caused by the spirochete Brachyspira hyodysenteriae and the typical manifestation is severe muco-haemorrhagic diarrhoea that may lead to a high mortality in affected herds if it is left untreated. The aim was to study the immunological and metabolic responses associated with swine dysentery. Pigs were orally inoculated with Brachyspira hyodysenteriae strain B204R after a provocative feeding regime with soy bean meal. Blood was sampled before inoculation and repeatedly during the incubation, dysentery and recovery periods. Counts of leucocyte and lymphocyte sub-populations and levels of the cytokines IL-1beta, IL-6, Il-10, TNF-alpha and IFN-gamma the acute phase protein Serum Amyolid A, glucose, lactate and 18 amino acids were determined. The experimental infection model was successful and ~65% of the pigs developed dysentery with a deterioration of the body condition and no weight gain. The presence of the pro-inflammatory cytokine IL-1beta in serum was associated with the manifestation of dysentery and the production of Serum amyloid A. During the dysentery period the numbers of monocytes, neutrophils and CD8alpha+ lymphocytes increased in the blood. Glucose and lactate levels showed no alteration during dysentery, but the serum concentrations of gluconeogenic amino acids, mainly glutamine, alanine, tyrosine and serine were decreased during that period. Most parameters were returned to their pre-inoculation levels during the recovery, but the presence of the anti-inflammatory cytokine IL-10 and the production of B. hyodysenteriae specific antibodies were associated with the recovery of sick animals. The susceptibility to disease after inoculation appeared to be related to low levels of CD8alpha+ lymphocytes and high levels of gamma/delta T cells in blood prior to inoculation. In conclusion, this thesis shows that the cellular and humoral immune responses as well as the metabolic response in blood were altered by swine dysentery.

Authors/Creators:Jonasson-Kruse, Robert
Title:Experimentally induced swine dysentery
Subtitle:with special reference to alterations in Lymphocyte sub-populations, cytokines and amino acids in blood
Series Name/Journal:Acta Universitatis Agriculturae Sueciae
Year of publishing :May 2007
Number of Pages:61
ALLI. Jonasson R, Johannisson A, Jacobson M, Fellström C, Jensen-Waern M. Differences in lymphocyte subpopulations and cell counts before and after experimentally induced swine dysentery. J Med Microbiol. 2004; 53: 267-72. II. Jonasson R, Andersson M, Råsbäck T, Johannisson A, Jensen-Waern M. Immunological alterations during the clinical and recovery phases of experimental swine dysentery. J Med Microbiol. 2006; 55: 845-55. III. Jonasson R, Essen-Gustavsson B, Fossum C, Jensen-Waern M. Blood concentrations of the cytokines IL-1β, IL-6, IL-10, TNF-α and IFN-γ during experimentally induced swine dysentery. Submitted 2007. IV. Jonasson R, Essen-Gustavsson B, Jensen-Waern M. Blood concentrations of amino acids, glucose and lactate during experimental swine dysentery. Res Vet Sci. 2007; 82: 323-331.
Place of Publication:Uppsala
ISBN for printed version:978-91-576-7315-2
Publication Type:Doctoral thesis
Full Text Status:Public
Agrovoc terms:swine, swine dysentery, infectious diseases, monocytes, blood cells, metabolism, amino acids, cytokines, antibodies
Keywords:Pigs, Brachyspira hyodysenteriae, infection, neutrophils, gamma/delta T cells, monocytes, CD8alpha, metabolism, amino acids, cytokines, antibodies.
Permanent URL:
ID Code:1438
Department:(VH) > Dept. of Clinical Sciences
Deposited By: Robert Jonasson-Kruse
Deposited On:10 May 2007 00:00
Metadata Last Modified:02 Dec 2014 10:12

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