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Expansion of spatial and host range of Puumala virus in Sweden: an increasing threat for humans?

Lindgren, Per-Erik and Alm Bergvall, Ulrika and Lundkvist, Åke and Kjellander, Petter and Wille, Michelle and Borg, O. and Chirico, J. (2017). Expansion of spatial and host range of Puumala virus in Sweden: an increasing threat for humans? Epidemiology and infection. 145, 1642-1648
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Abstract

Hantaviruses are globally distributed and cause severe human disease. Puumala hantavirus (PUUV) is the most common species in Northern Europe, and the only hantavirus confirmed to circulate in Sweden, restricted to the northern regions of the country. In this study, we aimed to further add to the natural ecology of PUUV in Sweden by investigating prevalence, and spatial and host species infection patterns. Specifically, we wanted to ascertain whether PUUV was present in the natural reservoir, the bank vole (Myodes glareolus) further south than Dalalven river, in south-central Sweden, and whether PUUV can be detected in other rodent species in addition to the natural reservoir. In total, 559 animals were collected at Grimso (59 degrees 43 ' N; 15 degrees 28 ' E), Sala (59 degrees 55 ' N; 16 degrees 36 ' E) and Bogesund (59 degrees 24 ' N; 18 degrees 14 ' E) in south-central Sweden between May 2013 and November 2014. PUUV ELISA-reactive antibodies were found both in 2013 (22/295) and in 2014 (18/264), and nine samples were confirmed as PUUV-specific by focus reduction neutralization test. Most of the PUUV-specific samples were from the natural host, the bank vole, but also from other rodent hosts, indicating viral spill-over. Finally, we showed that PUUV is present in more highly populated central Sweden.

Authors/Creators:Lindgren, Per-Erik and Alm Bergvall, Ulrika and Lundkvist, Åke and Kjellander, Petter and Wille, Michelle and Borg, O. and Chirico, J.
Title:Expansion of spatial and host range of Puumala virus in Sweden: an increasing threat for humans?
Series/Journal:Epidemiology and infection (1469-4409)
Year of publishing :2017
Volume:145
Page range:1642-1648
Number of Pages:7
Publisher:Cambridge University Press
ISSN:1469-4409
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Public Health, Global Health, Social Medicine and Epidemiology
Agrovoc terms:zoonoses, voles, hantavirus
Keywords:Bank vole, Bunyaviridae, disease emergence, hantavirus, Myodes glareolus, Puumala virus, Sweden, zoonosis
URN:NBN:urn:nbn:se:slu:epsilon-e-4437
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4437
Additional ID:
Type of IDID
DOI10.1017/S0950268817000346
Web of Science (WoS)000402918700015
ID Code:14626
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Ecology
(S) > Dept. of Ecology
Deposited By: SLUpub Connector
Deposited On:27 Oct 2017 09:17
Metadata Last Modified:30 Oct 2017 21:57

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