Feng, Chungang and Pettersson, Mats and Lamichhaney, Sangeet and Rubin, Carl-Johan and Rafati, Nima and Casini, Michele and Folkvord, Arild and Andersson, Leif
(2017).
Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate.
ELife. 6
, 1-14
[Research article]
![[img]](https://pub.epsilon.slu.se/style/images/fileicons/application_pdf.png) |
PDF
- Published Version
Available under License Creative Commons Attribution. 545kB |
Official URL: http://dx.doi.org/10.7554/eLife.23907
Abstract
The Atlantic herring is one of the most abundant vertebrates on earth but its nucleotide diversity is moderate (pi = 0.3%), only three-fold higher than in human. Here, we present a pedigree-based estimation of the mutation rate in this species. Based on whole-genome sequencing of four parents and 12 offspring, the estimated mutation rate is 2.0 x 10(-9) per base per generation. We observed a high degree of parental mosaicism indicating that a large fraction of these de novo mutations occurred during early germ cell development. The estimated mutation rate the lowest among vertebrates analyzed to date - partially explains the discrepancy between the rather low nucleotide diversity in herring and its huge census population size. But a species like the herring will never reach its expected nucleotide diversity because of fluctuations in population size over the millions of years it takes to build up high nucleotide diversity.
| Authors/Creators: | Feng, Chungang and Pettersson, Mats and Lamichhaney, Sangeet and Rubin, Carl-Johan and Rafati, Nima and Casini, Michele and Folkvord, Arild and Andersson, Leif | ||||||
|---|---|---|---|---|---|---|---|
| Title: | Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate | ||||||
| Series Name/Journal: | ELife | ||||||
| Year of publishing : | 2017 | ||||||
| Volume: | 6 | ||||||
| Page range: | 1-14 | ||||||
| Number of Pages: | 14 | ||||||
| Publisher: | eLife | ||||||
| ISSN: | 2050-084X | ||||||
| Language: | English | ||||||
| Publication Type: | Research article | ||||||
| Refereed: | Yes | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Agris subject categories.: | M Aquatic sciences and fisheries > M40 Aquatic ecology | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Fish and Aquacultural Science | ||||||
| Agrovoc terms: | herrings, mutation, genomes | ||||||
| Keywords: | nucleotide diversity, Atlantic herring, whole-genome sequencing, Clupea harengus, mutation rates, genetics | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-e-4593 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4593 | ||||||
| Additional ID: |
| ||||||
| ID Code: | 14899 | ||||||
| Faculty: | NJ - Fakulteten för naturresurser och jordbruksvetenskap | ||||||
| Department: | (NL, NJ) > Department of Aquatic Resources (NL, NJ) > Institutionen för husdjursgenetik (fr.o.m. 960101) | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 22 Jan 2018 13:14 | ||||||
| Metadata Last Modified: | 16 Aug 2020 17:49 |
Repository Staff Only: item control page
Relations
Relations