Srithunyarat, Thanikul and Hagman, Ragnvi and Höglund, Odd and Stridsberg, Mats and Hanson, Jeanette and Lagerstedt, Anne-Sofie and Pettersson, Ann
(2018).
Catestatin, vasostatin, cortisol, and visual analog scale scoring for stress assessment in healthy dogs.
Research in veterinary science. 117
, 74-80
[Research article]
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Available under License Creative Commons Attribution Non-commercial No Derivatives. 594kB |
Official URL: https://dx.doi.org/10.1016/j.rvsc.2017.11.015
Abstract
The neuroendocrine glycoprotein chromogranin A is a useful biomarker for stress in humans. Chromogranin A epitopes catestatin and vasostatin can be measured in dogs using radioimmunoassays. The objective of this study was to evaluate catestatin and vasostatin as canine stress biomarkers in a clinical setting. Blood and saliva were collected from 33 healthy dogs that were familiar with sampling procedures and the animal hospital environment (control group) and 30 healthy dogs that were unacquainted (stress group). During sampling, stress behavior was scored by the same observer using visual analog scale (VAS). Plasma was analyzed for catestatin and vasostatin, serum for cortisol, and saliva for catestatin. Differences between groups were analyzed using twosample t-tests and P < 0.05 was considered significant. Stress behavior VAS score in the control group was significantly lower than in the stress group during blood (P = 0.002) and saliva (P = 0.0009) sampling. Serum cortisol and saliva catestatin concentrations in the stress group were higher than the control group (P = 0.003 and P < 0.0001, respectively). Serum cortisol concentrations were correlated with those of saliva (r = 0.34, P = 0.04) and plasma catestatin (r = 0.29, P = 0.03). Plasma catestatin and vasostatin did not differ significantly between groups. In conclusion, concentrations of saliva catestatin, and serum cortisol, and stress behavior VAS scores were significantly higher in the stress group. The results indicate that saliva catestatin may be useful as a biomarker for acute psychological stress in dogs.
Authors/Creators: | Srithunyarat, Thanikul and Hagman, Ragnvi and Höglund, Odd and Stridsberg, Mats and Hanson, Jeanette and Lagerstedt, Anne-Sofie and Pettersson, Ann | ||||
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Title: | Catestatin, vasostatin, cortisol, and visual analog scale scoring for stress assessment in healthy dogs | ||||
Series Name/Journal: | Research in veterinary science | ||||
Year of publishing : | 2018 | ||||
Volume: | 117 | ||||
Page range: | 74-80 | ||||
Number of Pages: | 7 | ||||
Publisher: | Elsevier | ||||
ISSN: | 0034-5288 | ||||
Language: | English | ||||
Publication Type: | Research article | ||||
Refereed: | Yes | ||||
Article category: | Scientific peer reviewed | ||||
Version: | Published version | ||||
Copyright: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||
Full Text Status: | Public | ||||
Agris subject categories.: | L Animal production > L50 Animal physiology and biochemistry | ||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||
Agrovoc terms: | dogs, stress, biometry, behaviour | ||||
Keywords: | Biomarker, Canine, Chromogranin A, Psychological stress, Saliva | ||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-4603 | ||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4603 | ||||
Additional ID: |
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ID Code: | 14900 | ||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||
Department: | (VH) > Dept. of Clinical Sciences | ||||
Deposited By: | SLUpub Connector | ||||
Deposited On: | 11 Jan 2018 06:28 | ||||
Metadata Last Modified: | 11 Jan 2018 11:39 |
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