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Catestatin, vasostatin, cortisol, and visual analog scale scoring for stress assessment in healthy dogs

Srithunyarat, Thanikul and Hagman, Ragnvi and Höglund, Odd and Stridsberg, Mats and Hanson, Jeanette and Lagerstedt, Anne-Sofie and Pettersson, Ann (2018). Catestatin, vasostatin, cortisol, and visual analog scale scoring for stress assessment in healthy dogs. Research in veterinary science. 117, 74-80
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Official URL: https://dx.doi.org/10.1016/j.rvsc.2017.11.015

Abstract

The neuroendocrine glycoprotein chromogranin A is a useful biomarker for stress in humans. Chromogranin A epitopes catestatin and vasostatin can be measured in dogs using radioimmunoassays. The objective of this study was to evaluate catestatin and vasostatin as canine stress biomarkers in a clinical setting. Blood and saliva were collected from 33 healthy dogs that were familiar with sampling procedures and the animal hospital environment (control group) and 30 healthy dogs that were unacquainted (stress group). During sampling, stress behavior was scored by the same observer using visual analog scale (VAS). Plasma was analyzed for catestatin and vasostatin, serum for cortisol, and saliva for catestatin. Differences between groups were analyzed using twosample t-tests and P < 0.05 was considered significant. Stress behavior VAS score in the control group was significantly lower than in the stress group during blood (P = 0.002) and saliva (P = 0.0009) sampling. Serum cortisol and saliva catestatin concentrations in the stress group were higher than the control group (P = 0.003 and P < 0.0001, respectively). Serum cortisol concentrations were correlated with those of saliva (r = 0.34, P = 0.04) and plasma catestatin (r = 0.29, P = 0.03). Plasma catestatin and vasostatin did not differ significantly between groups. In conclusion, concentrations of saliva catestatin, and serum cortisol, and stress behavior VAS scores were significantly higher in the stress group. The results indicate that saliva catestatin may be useful as a biomarker for acute psychological stress in dogs.

Authors/Creators:Srithunyarat, Thanikul and Hagman, Ragnvi and Höglund, Odd and Stridsberg, Mats and Hanson, Jeanette and Lagerstedt, Anne-Sofie and Pettersson, Ann
Title:Catestatin, vasostatin, cortisol, and visual analog scale scoring for stress assessment in healthy dogs
Series/Journal:Research in veterinary science (0034-5288)
Year of publishing :2018
Volume:117
Page range:74-80
Number of Pages:7
Publisher:Elsevier
ISSN:0034-5288
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Agris subject categories.:L Animal production > L50 Animal physiology and biochemistry
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Agrovoc terms:dogs, stress, biometry, behaviour
Keywords:Biomarker, Canine, Chromogranin A, Psychological stress, Saliva
URN:NBN:urn:nbn:se:slu:epsilon-e-4603
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4603
Additional ID:
Type of IDID
DOI10.1016/j.rvsc.2017.11.015
ID Code:14900
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:11 Jan 2018 06:28
Metadata Last Modified:11 Jan 2018 11:39

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