studies of epidemiology, genetics, and autoantibodies
Bremer, Hanna
(2018).
Canine immune-mediated disease.
Diss. (sammanfattning/summary)
Uppsala :
Sveriges lantbruksuniv.,
Acta Universitatis Agriculturae Sueciae, 1652-6880
; 2018:13
ISBN 978-91-7760-166-1
eISBN 978-91-7760-167-8
[Doctoral thesis]
![]() |
PDF
1MB |
Abstract
Immune-mediated diseases in dogs constitute a large group of disorders with the common attribute that they are caused by dysfunctions in the immune system. Broadly they can be classified into immunodeficiency disorders, allergies, and autoimmune diseases. Earlier studies have suggested that dogs of the breed Nova Scotia duck tolling retriever (NSDTR) are at increased risk of developing immune-mediated disorders. Two disorders have received particular attention: immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). The major aims of this thesis were to 1) determine the incidence of immune-mediated disease in NSDTRs, 2) identify genetic risk factors for IMRD and SRMA, and 3) investigate the occurrence of different autoantibodies in dogs with autoimmune disease.
Data from Agria Pet Insurance were used to estimate incidence of disease. Incidence of different immune-mediated diseases in NSDTRs was compared with that in other dog breeds. In general, the incidence for autoimmune diseases was three times higher in NSDTRs compared to other breeds. For IMRD and SRMA, the incidences were >10 times higher.
Both IMRD and SRMA are complex genetic diseases and several genetic loci associated with the respective disease have been identified by our research group. We performed a detailed analysis of these loci and found 11 genes with altered gene expression associated with IMRD or SRMA. The majority of these genes were associated with either IMRD or with SRMA only, but one gene (AP3B2) showed association to both diseases.
Autoantibodies are important hallmarks of autoimmune diseases, including IMRD. In the studies presented in this thesis, different methods were used to identify the autoantibody targets in dogs that were positive for antinuclear autoantibodies. Both previously reported and new canine autoantibodies were found. The interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) appear to be common autoantibody targets in IMRD patients. These autoantibodies have not previously been described in dogs and have the potential to be used as diagnostic markers for canine systemic autoimmune disease.
Authors/Creators: | Bremer, Hanna | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Title: | Canine immune-mediated disease | ||||||||||
Subtitle: | studies of epidemiology, genetics, and autoantibodies | ||||||||||
Alternative abstract: |
| ||||||||||
Series Name/Journal: | Acta Universitatis Agriculturae Sueciae | ||||||||||
Year of publishing : | April 2018 | ||||||||||
Depositing date: | 19 April 2018 | ||||||||||
Number: | 2018:13 | ||||||||||
Number of Pages: | 67 | ||||||||||
Papers/manuscripts: |
| ||||||||||
Place of Publication: | Uppsala | ||||||||||
Publisher: | Department of Clinical Sciences, Swedish University of Agricultural Sciences | ||||||||||
ISBN for printed version: | 978-91-7760-166-1 | ||||||||||
ISBN for electronic version: | 978-91-7760-167-8 | ||||||||||
ISSN: | 1652-6880 | ||||||||||
Language: | English | ||||||||||
Publication Type: | Doctoral thesis | ||||||||||
Full Text Status: | Public | ||||||||||
Agris subject categories.: | L Animal production > L73 Animal diseases | ||||||||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||||||
Agrovoc terms: | dogs, autoimmune diseases, autoimmunity, antibodies, immunological factors, arthritis, gene expression, animal diseases | ||||||||||
Keywords: | Antinuclear antibodies, autoimmunity, dog, gene expression, ILF2, ILF3, immune-mediated rheumatic disease, Nova Scotia duck tolling retriever, steroid-responsive meningitis-arteritis, systemic lupus erythematosus | ||||||||||
URN:NBN: | urn:nbn:se:slu:epsilon-e-4835 | ||||||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4835 | ||||||||||
ID Code: | 15432 | ||||||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||||||
Department: | (VH) > Dept. of Clinical Sciences | ||||||||||
External funders: | Agria and Uppsala University and Swedish Research Council | ||||||||||
Deposited By: | H.D. Bremer | ||||||||||
Deposited On: | 25 Apr 2018 10:05 | ||||||||||
Metadata Last Modified: | 09 Sep 2020 14:17 |
Repository Staff Only: item control page