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ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease

Bremer, Hanna and Landegren, Nils and Sjöberg, Roland and Hallgren, Åsa and Renneker, Stefanie and Lattwein, Erik and Leonard, Dag and Eloranta, Maija-Leena and Rönnblom, Lars and Nordmark, Gunnel and Nilsson, Peter and Andersson, Göran and Lilliehöök, Inger and Lindblad-Toh, Kerstin and Kämpe, Olle and Hansson-Hamlin, Helene (2018). ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease. Scientific Reports. 8 , 1-9
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Abstract

Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. The ILF2 autoantibodies were discovered in a small, selected canine cohort through the use of human protein arrays; a method not previously described in dogs. Subsequently, ILF3 autoantibodies were also identified in the same cohort. The results were validated with an independent method in a larger cohort of dogs. ILF2 and ILF3 autoantibodies were found exclusively, and at a high frequency, in dogs that showed a speckled pattern of antinuclear antibodies on immunofluorescence. ILF2 and ILF3 autoantibodies were also found at low frequency in human patients with SLE and Sjogren's syndrome. These autoantibodies have the potential to be used as diagnostic biomarkers for canine, and possibly also human, autoimmune disease.

Authors/Creators:Bremer, Hanna and Landegren, Nils and Sjöberg, Roland and Hallgren, Åsa and Renneker, Stefanie and Lattwein, Erik and Leonard, Dag and Eloranta, Maija-Leena and Rönnblom, Lars and Nordmark, Gunnel and Nilsson, Peter and Andersson, Göran and Lilliehöök, Inger and Lindblad-Toh, Kerstin and Kämpe, Olle and Hansson-Hamlin, Helene
Title:ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Series/Journal:Scientific Reports (2045-2322)
Year of publishing :2018
Volume:8
Page range:1-9
Number of Pages:9
Publisher:Macmillan Publishers Limited, part of Springer Nature
ISSN:2045-2322
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Other Veterinary Science
Agrovoc terms:autoimmune diseases, dogs
Keywords:Lupus-erythematosus, Antinuclear antibodies, T-cells, autoantibodies, dogs, protein, expression
URN:NBN:urn:nbn:se:slu:epsilon-e-4900
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-4900
Additional ID:
Type of IDID
DOI10.1038/s41598-018-23034-w
Web of Science (WoS)000427688100045
ID Code:15489
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:25 May 2018 09:14
Metadata Last Modified:09 Sep 2020 14:17

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