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Metabolic variations in canine overweight

aspects of lipid metabolism in spontaneously overweight Labrador Retriever dogs

Söder, Josefin (2018). Metabolic variations in canine overweight. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis Agriculturae Sueciae, 1652-6880 ; 2018:62
ISBN 978-91-7760-264-4
eISBN 978-91-7760-265-1
[Doctoral thesis]

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Abstract

The prevalence of overweight in dogs is increasing. Canine overweight is associated with reduced quality of life, shorter life expectancy and metabolic variations such as insulin resistance and postprandial hyperlipidaemia. Previous metabolic research on overweight dogs has been performed mainly in fasting condition and studies on spontaneously overweight dogs using dynamic metabolic tests are scarce. This thesis therefore evaluated metabolic variations in spontaneously overweight dogs using a feed-challenge test.

Lean and overweight healthy Labrador Retriever dogs underwent a feed-challenge test. Blood and urine samples collected at fasting and after food intake were analysed with serum biochemistry, ELISA and metabolomics techniques. Multivariate and mixed model repeated measurements analyses were used to evaluate responses between body condition groups and/or between time points in the feed-challenge test.

Postprandial serum triglycerides were higher in prominently overweight dogs compared with lean, while no differences between groups were found at fasting. Only one fasted plasma phosphatidylcholine showed higher concentration in prominently overweight compared with lean dogs. Postprandial urine metabolomes, but not fasting metabolomes, distinguished between lean and overweight groups of dogs. Prominently overweight dogs had higher fasting urine cortisol/creatinine ratio than lean dogs, and overweight dogs showed signs of amino acid catabolism in postprandial urine. The acetylcarnitine response in overweight dogs indicated low fatty acid oxidation at fasting and metabolic inflexibility to food intake. Overweight dogs also showed lower carnitine and taurine status than lean dogs, potentially representing an interrelated insufficiency that could theoretically slow down lipid metabolism.

In conclusion, spontaneously overweight Labrador Retriever dogs displayed variations in metabolic parameters compared with lean dogs. Use of a feed-challenge test allowed detection of subtle metabolic variations not noticeable in fasted condition, emphasising the importance of using dynamic tests in metabolic research on canine overweight. Six parameters, all directly or indirectly associated with lipid metabolism, differed between overweight and lean dogs. In this thesis, the complexity of lipid metabolism in canine overweight was revealed by identifying previously known and new metabolic variations in spontaneously overweight Labrador Retriever dogs.

Authors/Creators:Söder, Josefin
Title:Metabolic variations in canine overweight
Subtitle:aspects of lipid metabolism in spontaneously overweight Labrador Retriever dogs
Series/Journal:Acta Universitatis Agriculturae Sueciae (1652-6880)
Year of publishing :2018
Depositing date:29 October 2018
Volume:2018:62
Number of Pages:88
Papers/manuscripts:
NumberReferences
ISöder J.*, Wernersson S., Hagman R., Karlsson I., Malmlöf K., Höglund K. (2016). Metabolic and hormonal response to a feed-challenge test in lean and overweight dogs. Journal of Veterinary Internal Medicine, 30, pp. 574-582.
IISöder J.*, Hagman R., Dicksved J., Lindåse S., Malmlöf K., Agback P., Moazzami A.A., Höglund K., Wernersson S. (2017). The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge. PloS one, 12, pp. 0180086.
IIISöder J.*, Höglund K., Dicksved J., Hagman R., Röhnisch HE., Moazzami A.A., Wernersson S. Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs. (Submitted)
IVSöder J., Wernersson S., Dicksved J., Hagman R., Östman J., Moazzami A.A., Höglund K. Indication of metabolic inflexibility to food intake in spontaneously overweight Labrador Retriever dogs. (Manuscript).
Place of Publication:Uppsala
Publisher:Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences
Associated Programs and Other Stakeholders:SLU - Research Areas for the Future > Future Animal Health and Welfare (until Jan 2017)
ISBN for printed version:978-91-7760-264-4
ISBN for electronic version:978-91-7760-265-1
ISSN:1652-6880
Language:English
Additional Information:The work in this thesis was generously supported by the research platform Future Animal Health and Welfare, SLU, Thure F. och Karin Forsbergs Stiftelse, Stockholm, Sällskapsdjurens forskningsfond, SLU, Michael Forsgrens stiftelse, SLU, VH-fakultetens stipendier, SLU, and Resestipendium, SLU.
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L51 Animal physiology - Nutrition
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Nutrition and Dietetics
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Medical Bioscience
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Canine overweight, Postprandial metabolism, Feed-challenge test, Metabolomics, Lipid metabolism, Metabolic inflexibility, Carnitine, Taurine, Obesity, Acetylcarnitine
URN:NBN:urn:nbn:se:slu:epsilon-e-5087
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-e-5087
ID Code:15727
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: DVM Josefin Söder
Deposited On:31 Oct 2018 08:29
Metadata Last Modified:31 Oct 2018 08:29

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