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Perfluoroalkyl Acids (PFAAs) in Serum from 2-4-Month-Old Infants: Influence of Maternal Serum Concentration, Gestational Age, Breast-Feeding, and Contaminated Drinking Water

Gyllenhammar, Irina and Benskin, Jonathan P. and Sandblom, Oskar and Berger, Urs and Ahrens, Lutz and Lignell, Sanna and Wiberg, Karin and Glynn, Anders (2018). Perfluoroalkyl Acids (PFAAs) in Serum from 2-4-Month-Old Infants: Influence of Maternal Serum Concentration, Gestational Age, Breast-Feeding, and Contaminated Drinking Water. Environmental Science and Technology. 52 , 7101-7110
[Journal article]

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Official URL: https://doi.org/10.1021/acs.est.8b00770

Abstract

Little is known about factors influencing infant perfluorinated alkyl acid (PFAA) concentrations. Associations between serum PFAA concentrations in 2-4-month-old infants (n = 101) and determinants were investigated by multiple linear regression and general linear model analysis. In exclusively breastfed infants, maternal serum PFAA concentrations 3 weeks after delivery explained 13% (perfluoroundecanoic acid, PFUnDA) to 73% (perfluorohexanesulfonate, PFHxS) of infant PFAA concentration variation. Median infant/maternal ratios decreased with increasing PFAA carbon chain length from 2.8 for perfluoroheptanoic acid and perfluorooctanoic acid (PFOA) to 0.53 for PFUnDA and from 1.2 to 0.69 for PFHxS and perfluorooctanesulfonate (PFOS). Infant PFOA, perfluorononanoic acid (PFNA), and PFOS levels increased 0.7-1.2% per day of gestational age. Bottle-fed infants had mean concentrations of PFAAs 2 times lower than and a mean percentage of branched (%br) PFOS isomers 1.3 times higher than those of exclusively breast-fed infants. PFOA, PFNA, and PFHxS levels increased 8-11% per week of exclusive breast-feeding. Infants living in an area receiving PFAA-contaminated drinking water had 3-fold higher mean perfluorobutanesulfonate (PFBS) and PFHxS concentrations and higher mean %br PFHxS. Prenatal PFAA exposure and postnatal PFAA exposure significantly contribute to infant PFAA serum concentrations, depending on PFAA carbon chain length. Moderately PFBS- and PFHxS-contaminated drinking water is an important indirect exposure source.

Authors/Creators:Gyllenhammar, Irina and Benskin, Jonathan P. and Sandblom, Oskar and Berger, Urs and Ahrens, Lutz and Lignell, Sanna and Wiberg, Karin and Glynn, Anders
Title:Perfluoroalkyl Acids (PFAAs) in Serum from 2-4-Month-Old Infants: Influence of Maternal Serum Concentration, Gestational Age, Breast-Feeding, and Contaminated Drinking Water
Year of publishing :2018
Volume:52
Page range:7101-7110
Number of Pages:10
Publisher:American Chemical Society
ISSN:0013-936X
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Public Health, Global Health, Social Medicine and Epidemiology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:PERFLUORINATED ALKYL ACIDS, POLYFLUOROALKYL SUBSTANCES, TRANSPLACENTAL TRANSFER, POSTNATAL EXPOSURE, PLACENTAL-TRANSFER, MASS-SPECTROMETRY, FETAL-GROWTH, CORD SERUM, MILK, SULFONATE
URN:NBN:urn:nbn:se:slu:epsilon-p-95937
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-95937
Additional ID:
Type of IDID
DOI10.1021/acs.est.8b00770
Web of Science (WoS)000436018900042
ID Code:16054
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
VH - Faculty of Veterinary Medicine and Animal Science
Department:(NL, NJ) > Dept. of Aquatic Sciences and Assessment
(VH) > Dept. of Animal Environment and Health
Deposited By: SLUpub Connector
Deposited On:11 Apr 2019 11:39
Metadata Last Modified:16 May 2019 23:15

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