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Disentangling host-parasite-pathogen interactions in a varroa-resistant honeybee population reveals virus tolerance as an independent, naturally adapted survival mechanism

Thaduri, Srinivas and Stephan, Jörg and Rodrigues De Miranda, Joachim and Locke, Barbara (2019). Disentangling host-parasite-pathogen interactions in a varroa-resistant honeybee population reveals virus tolerance as an independent, naturally adapted survival mechanism. Scientific Reports. 9 , 1-10
[Journal article]

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Official URL: https://doi.org/10.1038/s41598-019-42741-6

Abstract

The ectoparasitic mite, Varroa destructor, is unarguably the leading cause of honeybee (Apis mellifera) mortality worldwide through its role as a vector for lethal viruses, in particular, strains of the Deformed wing virus (DWV) and Acute bee paralysis virus (ABPV) complexes. This multi-level system of hostparasite-pathogen interactions makes it difcult to investigate efects of either the mite or the virus on natural host survival. The aim of this study was to remove confounding efects of varroa to examine the role of virus susceptibility in the enhanced survival of a naturally adapted Swedish mite-resistant (MR) honeybee population, relative to mite-susceptible (MS) honeybees. Caged adult bees and laboratory reared larvae, from varroa-free colonies, were inoculated with DWV and ABPV in a series of feeding infection experiments, while control groups received virus-free food. Virus infections were monitored using RT-qPCR assays in individuals sampled over a time course. In both adults and larvae the DWV and ABPV infection dynamics were nearly identical between MR and MS groups, but MS adults sufered signifcantly higher mortality than MR adults. Results suggest virus tolerance, rather than reduced susceptibility or virus resistance, is an important component of the natural survival of this honeybee population.

Authors/Creators:Thaduri, Srinivas and Stephan, Jörg and Rodrigues De Miranda, Joachim and Locke, Barbara
Title:Disentangling host-parasite-pathogen interactions in a varroa-resistant honeybee population reveals virus tolerance as an independent, naturally adapted survival mechanism
Year of publishing :2019
Volume:9
Page range:1-10
Number of Pages:10
Publisher:NatureResearch
ISSN:2045-2322
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology
Keywords:honeybees, Apis mellifera, parasites, ectoparasitic mites, Varroa destructor, mite-resistance, virus resistance, RT-qPCR assays
URN:NBN:urn:nbn:se:slu:epsilon-p-99881
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-99881
Additional ID:
Type of IDID
DOI10.1038/s41598-019-42741-6
ID Code:16114
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Ecology
(S) > Dept. of Ecology
Deposited By: SLUpub Connector
Deposited On:21 May 2019 10:58
Metadata Last Modified:21 May 2019 10:58

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