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Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells

Zubair, Muhammad and Widen, Cecilia and Renvert, Stefan and Rumpunen, Kimmo (2019). Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells. Journal of traditional and complementary medicine. 9, 169-171
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Abstract

Context: The leaves of Plantago major have been used for the treatment of wounds and inflammation in folk medicine from prehistoric times. However there is no report on the use of P. major to treat inflammation in oral epithelial cell lines.
Objective: The present study was undertaken to reveal possible anti-inflammatory effects of Plantago major leaf extracts on oral epithelial cells in-vitro.
Materials and methods: Water- and ethanol-based extracts of P. major leaves were prepared from freezedried plant material, and tested in-vitro using the oral epithelial cell line H400. The anti-inflammatory activity of P. major was tested against E. coli lipopolysaccharide (LPS) using the nuclear factor kappa beta (NF-kB) assay.
Results: Both the water- and the ethanol-based extracts, as well as a combination of the two extracts, showed anti-inflammatory activity. A concentration of 0.1 mg/mL (on dry weight basis) yielded the best results for all extracts. Discussion and conclusion: The results show that synergistic effects of both polyphenols and watersoluble compounds (possibly polysaccharides) are responsible for anti-inflammatory activities of P. major.

Authors/Creators:Zubair, Muhammad and Widen, Cecilia and Renvert, Stefan and Rumpunen, Kimmo
Title:Water and ethanol extracts of Plantago major leaves show anti-inflammatory activity on oral epithelial cells
Year of publishing :2019
Volume:9
Page range:169-171
Number of Pages:3
Publisher:Center for Food and Biomolecules, National Taiwan University
Associated Programs and Other Stakeholders:Z - SLU - Libray > Odla mera
ISSN:2225-4110
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Agricultural Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Horticulture
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Other Health Sciences
Keywords:Common plantain, Herbal medicine, NF-kB, Wound healing
URN:NBN:urn:nbn:se:slu:epsilon-p-100447
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-100447
Additional ID:
Type of IDID
DOI10.1016/j.jtcme.2017.09.002
ID Code:16202
Faculty:LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap
Department:(LTJ, LTV) > Department of Plant Breeding (from 130101)
Deposited By: SLUpub Connector
Deposited On:04 Jul 2019 07:25
Metadata Last Modified:05 Jul 2019 04:02

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