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Effect-based environmental monitoring for thyroid disruption in Swedish amphibian tadpoles

Carlsson, Gunnar (2019). Effect-based environmental monitoring for thyroid disruption in Swedish amphibian tadpoles. Environmental Monitoring and Assessment. 191 , 1-18
[Journal article]

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Abstract

It is well-known that the metamorphosis process in amphibians is dependent on thyroid hormones. Laboratory studies have shown that several environmental contaminants can affect the function of thyroid hormones leading to alterations in the amphibian metamorphosis. The basic idea of the present study was to elucidate if the amphibian metamorphosis might be a useful tool as biomarker for effect-based environmental monitoring, examining wild tadpoles for potential thyroid hormone disruption. A laboratory test was performed to identify the responses from exposure to 6- propylthiouracil (PTU), which has a well-known mechanism on the thyroid system, on Swedish tadpoles from the Rana genus. This was followed by an environmental monitoring study where tadpoles of Rana arvalis, R. temporaria, and Bufo bufo were sampled from various sites in Sweden. Morphological data such as body weight, histopathological measurements of the thyroid glands, and environmental parameters were recorded. The results revealed that Rana tadpoles respond similar as other amphibians to PTU exposure, with interrupted development and increased size relative to the developmental stage. Data on some wild tadpoles showed similar features as the PTU exposed, such as high body weight, thus suggesting potential thyroid disrupting effects. However, histological evaluation of thyroid glands and pesticide analyses of the water revealed no clear evidence of chemical interactions. To a minor degree, the changes in body weight may be explained by natural circumstances such as pH, forest cover, and temperature. The present study cannot fully explain whether the high body weights recorded in some tadpoles have natural or chemical explanations. However, the study reveals that it is clearly achievable to catch tadpoles in suitable stages for the use in this type of biomonitoring and that the use of these biomarkers for assessment of thyroid disruption seems to be highly relevant.

Authors/Creators:Carlsson, Gunnar
Title:Effect-based environmental monitoring for thyroid disruption in Swedish amphibian tadpoles
Year of publishing :2019
Volume:191
Page range:1-18
Number of Pages:18
Publisher:Springer
Associated Programs and Other Stakeholders:SLU - Environmental assessment > Programme Non-Toxic Environment
ISSN:0167-6369
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Other Biological Topics
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Zoology
Keywords:Rana arvalis, Rana temporaria, Bufo bufo, Metamorphosis, Biomarkers
URN:NBN:urn:nbn:se:slu:epsilon-p-100658
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-100658
Additional ID:
Type of IDID
DOI10.1007/s10661-019-7590-1
ID Code:16224
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:11 Jul 2019 06:51
Metadata Last Modified:15 Jan 2020 03:45

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