Glynn, Anders and Lignell, Sanna
(2019).
Increased urinary excretion of aluminium after ingestion of the food additive sodidum aluminium phosphate (SALP) - a study on healthy volunteers.
Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment. 36
, 1236-1243
[Research article]
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Abstract
Food is an important source of human aluminium (Al) exposure and regular consumption of foods containing Al-based food additives may result in high Al intakes above health-based tolerable intakes. However, some additives are Al salts with low solubility, and little is known about bioavailability of Al in these additives. We investigated urine Al concentrations in healthy adult volunteers (N = 18, women/men) before (base-line) and after 7 days of ingestion of pancakes with a low Al content (median: <0.5 mg Al/kg) and high Al content (median: 860 mg/kg). The high-Al pancakes contained the common additive sodium aluminium phosphate (SALP). The participants did not know if the pancakes contained SALP or not during the experiment. After adjusting for creatinine content of the urine samples, median base-line Al concentrations before pancake ingestion were in the range 30–40 µmol Al/mol creatinine. Urine Al concentrations after ingestion of low-Al pancakes (average intake: <0.042 Al mg/day) did not differ significantly from the base-line levels. After ingestion of high-Al pancakes (72 mg Al/day) the median Al concentration in urine was more than 2-fold higher than at the base-line sampling before the high-Al pancake ingestion. At the end of the experiment the volunteers ingested an Al-containing antacid (Al-OH, 1800 mg Al/day) for 7 days as a positive control of Al absorption. This caused a 10-fold increase in median urine Al concentration compared to baseline. Our results strongly suggest that Al in the form of SALP in a pancake mix is bioavailable for absorption in humans, which should be taken into account in risk assessment of Al in food in countries with a high use of SALP as a food additive.
Authors/Creators: | Glynn, Anders and Lignell, Sanna | ||||
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Title: | Increased urinary excretion of aluminium after ingestion of the food additive sodidum aluminium phosphate (SALP) - a study on healthy volunteers | ||||
Series Name/Journal: | Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment | ||||
Year of publishing : | 2019 | ||||
Volume: | 36 | ||||
Page range: | 1236-1243 | ||||
Number of Pages: | 8 | ||||
Publisher: | Taylor & Francis | ||||
ISSN: | 1944-0049 | ||||
Language: | English | ||||
Publication Type: | Research article | ||||
Refereed: | Yes | ||||
Article category: | Scientific peer reviewed | ||||
Version: | Published version | ||||
Copyright: | Creative Commons: Attribution 4.0 | ||||
Full Text Status: | Public | ||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Food Science | ||||
Keywords: | Aluminium, exposure, food, antacid, urine | ||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-101953 | ||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-101953 | ||||
Additional ID: |
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ID Code: | 16375 | ||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||
Department: | (VH) > Dept. of Biomedical Sciences and Veterinary Public Health | ||||
Deposited By: | SLUpub Connector | ||||
Deposited On: | 14 Nov 2019 09:42 | ||||
Metadata Last Modified: | 14 Nov 2019 09:42 |
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