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Perfluoroalkyl acids (PFAAs) in children’s serum and contribution from PFAA-contaminated drinking water

Gyllenhammar, Irina and Benskin, Jonathan P. and Sandblom, Oskar and Berger, Urs and Ahrens, Lutz and Lignell, Sanna and Wiberg, Karin and Glynn, Anders (2019). Perfluoroalkyl acids (PFAAs) in children’s serum and contribution from PFAA-contaminated drinking water. Environmental Science and Technology. 53 :19 , 11447−11457
[Journal article]

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Abstract

We investigated associations between serum perfluoroalkyl acid (PFAA) concentrations in children aged 4, 8, and 12 years (sampled in 2008–2015; n = 57, 55, and 119, respectively) and exposure via placental transfer, breastfeeding, and ingestion of PFAA-contaminated drinking water. Sampling took place in Uppsala County, Sweden, where the drinking water has been historically contaminated with perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluoroheptanoate (PFHpA), and perfluorooctanoate (PFOA). PFOS showed the highest median concentrations in serum (3.8–5.3 ng g–1 serum), followed by PFHxS (1.6–5.0 ng g–1 serum), PFOA (2.0–2.5 ng g–1 serum), and perfluorononanoate (PFNA) (0.59–0.69 ng g–1 serum) in children. Including all children, serum PFOA, PFHxS, and PFOS concentrations in children increased 10, 10, and 1.3% (adjusted mean), respectively, per unit (ng g–1 serum) of increase in the maternal serum level (at delivery), the associations being strongest for 4 year-old children. PFHxS and PFOS significantly increased 3.9 and 3.8%, respectively, per month of nursing, with the highest increase for 4 year-olds. PFOA, PFBS, PFHxS, and PFOS increased 1.2, 207, 7.4, and 0.93%, respectively, per month of cumulative drinking water exposure. Early life exposure to PFOA, PFHxS, and PFOS is an important determinant of serum concentrations in children, with the strongest influence on younger ages. Drinking water with low to moderate PFBS, PFHxS, PFOS, and PFOA contamination is an important source of exposure for children with background exposure from other sources.

Authors/Creators:Gyllenhammar, Irina and Benskin, Jonathan P. and Sandblom, Oskar and Berger, Urs and Ahrens, Lutz and Lignell, Sanna and Wiberg, Karin and Glynn, Anders
Title:Perfluoroalkyl acids (PFAAs) in children’s serum and contribution from PFAA-contaminated drinking water
Year of publishing :2019
Volume:53
Number:19
Page range:11447−11457
Number of Pages:11
Publisher:American Chemical Society
ISSN:0013-936X
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Accepted version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:Early-life exposure, Perfluorinated compunds, Perfluorooctane sulfonate, Polyfluoroalkyl compunds, Placental transfer, postnatal exposure, prenatal exposure, temporal trend, fetal growth, human milk, drinking water
URN:NBN:urn:nbn:se:slu:epsilon-p-101954
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-101954
Additional ID:
Type of IDID
DOI10.1021/acs.est.9b01746
ID Code:16380
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
VH - Faculty of Veterinary Medicine and Animal Science
Department:(NL, NJ) > Dept. of Aquatic Sciences and Assessment
(VH) > Dept. of Biomedical Sciences and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:29 Oct 2019 08:14
Metadata Last Modified:20 Sep 2020 23:15

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