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Demography, heritability and genetic correlation of feline hip dysplasia and response to selection in a health screening programme

Low, Matthew and Eksell, Per and Högström, Kjell and Olsson, Ulrika and Audell, Lars and Ohlsson, Åsa (2019). Demography, heritability and genetic correlation of feline hip dysplasia and response to selection in a health screening programme. Scientific Reports. 9 , 1-9
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Abstract

Feline hip dysplasia (FHD) is a debilitating condition affecting the hip joints of millions of domestic cats worldwide. Despite this, little is known about FHD except that it is relatively common in the large breed Maine Coon. We used 20 years of data from 5038 pedigree-registered Maine Coon cats in a radiographic health screening programme for FHD to determine, for the first time, its heritability, genetic correlation to body mass and response to selection. FHD prevalence was 37.4%, with no sex predilection; however, FHD severity increased with age and body mass. Heritability of the radiographic categories used to classify FHD severity was 0.36 (95%CI: 0.30-0.43). The severity of FHD symptoms was also genetically correlated with body mass (0.285), suggesting that selection for a large body type in this breed concurrently selects for FHD. Support for this was found by following generational responses to selective breeding against FHD. Not only did selective breeding successfully reduce the severity of FHD symptoms in descendants, but these cats were also smaller than their ancestors (-33g per generation). This study highlights the value of breeding programmes against FHD and cautions against breed standards that actively encourage large bodied cats.

Authors/Creators:Low, Matthew and Eksell, Per and Högström, Kjell and Olsson, Ulrika and Audell, Lars and Ohlsson, Åsa
Title:Demography, heritability and genetic correlation of feline hip dysplasia and response to selection in a health screening programme
Year of publishing :2019
Volume:9
Page range:1-9
Number of Pages:9
Publisher:NatureResearch
ISSN:2045-2322
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 404 Agricultural Biotechnology > Genetics and Breeding
Keywords:Feline hip dysplasia (FHD), domestic cats, Maine Coon cats, heritability
URN:NBN:urn:nbn:se:slu:epsilon-p-102670
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-102670
Additional ID:
Type of IDID
DOI10.1038/s41598-019-53904-w
Web of Science (WoS)000497712000009
ID Code:16484
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:03 Feb 2020 11:57
Metadata Last Modified:03 Feb 2020 11:57

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