Home About Browse Search
Svenska


Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna

Motiei, Asa and Brindefalk, Björn and Ogonowski, Martin and El-Shehawy, Rehab and Pastuszek, Paulina and Ek, Karin and Liewenborg, Birgitta and Udekwu, Klas and Gorokhova, Elena (2020). Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna. PLoS ONE. 15 :1 , 1-22
[Journal article]

[img] PDF - Published Version
Available under License Creative Commons Attribution.

1MB

Abstract

It is a common view that an organism’s microbiota has a profound influence on host fitness; however, supporting evidence is lacking in many organisms. We manipulated the gut microbiome of Daphnia magna by chronic exposure to different concentrations of the antibiotic Ciprofloxacin (0.01–1 mg L-1), and evaluated whether this affected the animals fitness and antioxidant capacity. In line with our expectations, antibiotic exposure altered the microbiome in a concentration-dependent manner. However, contrary to these expectations, the reduced diversity of gut bacteria was not associated with any fitness detriment. Moreover, the growth-related parameters correlated negatively with microbial diversity; and, in the daphnids exposed to the lowest Ciprofloxacin concentrations, the antioxidant capacity, growth, and fecundity were even higher than in control animals. These findings suggest that Ciprofloxacin exerts direct stimulatory effects on growth and reproduction in the host, while microbiome- mediated effects are of lesser importance. Thus, although microbiome profiling of Daphnia may be a sensitive tool to identify early effects of antibiotic exposure, disentangling direct and microbiome-mediated effects on the host fitness is not straightforward.

Authors/Creators:Motiei, Asa and Brindefalk, Björn and Ogonowski, Martin and El-Shehawy, Rehab and Pastuszek, Paulina and Ek, Karin and Liewenborg, Birgitta and Udekwu, Klas and Gorokhova, Elena
Title:Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna
Year of publishing :2020
Volume:15
Number:1
Page range:1-22
Number of Pages:22
Publisher:PLoS
ISSN:1932-6203
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109)
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Biochemistry and Molecular Biology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:gut microbiome, Daphnia magna, antibiotics, Ciprofloxacin, fitness
URN:NBN:urn:nbn:se:slu:epsilon-p-103301
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-103301
Additional ID:
Type of IDID
DOI10.1371/journal.pone.0214833
ID Code:16543
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Aquatic Resources
Deposited By: SLUpub Connector
Deposited On:20 Feb 2020 08:03
Metadata Last Modified:20 Feb 2020 08:03

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits