Truelsen Lindåse, Sanna and Nostell, Katarina and Söder, Josefin and Bröjer, Johan
(2017).
Relationship Between β-cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp.
Journal of Veterinary Internal Medicine. 31
, 1541-1550
[Research article]
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Abstract
Background: A hyperbolic relationship between beta-cell response and insulin sensitivity (IS) has been described in several species including rodents, dogs, and humans. This relationship has not been elucidated in the horse.
Hypothesis/Objectives: To determine whether the hyperbolic relationship between beta-cell response and IS exists in horses by using indices of beta-cell response from the oral sugar test (OST) and IS measurements from the euglycemic hyperinsulinemic clamp (EHC). A second aim was to compare how well IS estimates from the OST and EHC correlate.
Animals: Forty-nine horses with different degrees of insulin regulation (normal-to-severe insulin dysregulation).
Methods: Cross-sectional study. Horses were examined with an OST and an EHC.
Results: Decreased IS was associated with increased beta-cell response in the horses. Nine of 12 comparisons between indices of beta-cell response and IS measures fulfilled the criteria for a hyperbolic relationship. Indices of IS calculated from the OST correlated highly with the insulin-dependent glucose disposal rate (M) and the insulin-dependent glucose disposal rate per unit of insulin (M/I) determined from the EHC (r = 0.81-0.87).
Conclusions and Clinical Importance: A hyperbolic relationship between beta-cell response and IS exists in horses, which suggest that horses with insulin dysregulation respond not only with postprandial hyperinsulinemia but are also insulin resistant. The OST is primarily a test for beta-cell response rather than a test for IS, but calculated indices of IS from the OST may be useful to estimate IS in horses, especially when the horse is insulin resistant.
| Authors/Creators: | Truelsen Lindåse, Sanna and Nostell, Katarina and Söder, Josefin and Bröjer, Johan | ||||||
|---|---|---|---|---|---|---|---|
| Title: | Relationship Between β-cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp | ||||||
| Series Name/Journal: | Journal of Veterinary Internal Medicine | ||||||
| Year of publishing : | 2017 | ||||||
| Volume: | 31 | ||||||
| Page range: | 1541-1550 | ||||||
| Number of Pages: | 10 | ||||||
| Publisher: | Wiley Periodicals, Inc., American College of Veterinary Internal Medicine | ||||||
| ISSN: | 0891-6640 | ||||||
| Language: | English | ||||||
| Publication Type: | Research article | ||||||
| Refereed: | Yes | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution-Noncommercial 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Medical Bioscience (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||
| Keywords: | Equine metabolic syndrome, Hyperbolic relationship, Insulin dysregulation, Insulin resistance | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-86994 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-86994 | ||||||
| Additional ID: |
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| ID Code: | 16688 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Dept. of Clinical Sciences (VH) > Dept. of Anatomy, Physiology and Biochemistry | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 06 Mar 2020 10:28 | ||||||
| Metadata Last Modified: | 08 Apr 2020 21:32 |
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