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Relationship Between β-cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp

Truelsen Lindåse, Sanna and Nostell, Katarina and Söder, Josefin and Bröjer, Johan (2017). Relationship Between β-cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp. Journal of Veterinary Internal Medicine. 31 , 1541-1550
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Abstract

Background: A hyperbolic relationship between beta-cell response and insulin sensitivity (IS) has been described in several species including rodents, dogs, and humans. This relationship has not been elucidated in the horse.
Hypothesis/Objectives: To determine whether the hyperbolic relationship between beta-cell response and IS exists in horses by using indices of beta-cell response from the oral sugar test (OST) and IS measurements from the euglycemic hyperinsulinemic clamp (EHC). A second aim was to compare how well IS estimates from the OST and EHC correlate.
Animals: Forty-nine horses with different degrees of insulin regulation (normal-to-severe insulin dysregulation).
Methods: Cross-sectional study. Horses were examined with an OST and an EHC.
Results: Decreased IS was associated with increased beta-cell response in the horses. Nine of 12 comparisons between indices of beta-cell response and IS measures fulfilled the criteria for a hyperbolic relationship. Indices of IS calculated from the OST correlated highly with the insulin-dependent glucose disposal rate (M) and the insulin-dependent glucose disposal rate per unit of insulin (M/I) determined from the EHC (r = 0.81-0.87).
Conclusions and Clinical Importance: A hyperbolic relationship between beta-cell response and IS exists in horses, which suggest that horses with insulin dysregulation respond not only with postprandial hyperinsulinemia but are also insulin resistant. The OST is primarily a test for beta-cell response rather than a test for IS, but calculated indices of IS from the OST may be useful to estimate IS in horses, especially when the horse is insulin resistant.

Authors/Creators:Truelsen Lindåse, Sanna and Nostell, Katarina and Söder, Josefin and Bröjer, Johan
Title:Relationship Between β-cell Response and Insulin Sensitivity in Horses based on the Oral Sugar Test and the Euglycemic Hyperinsulinemic Clamp
Year of publishing :2017
Volume:31
Page range:1541-1550
Number of Pages:10
Publisher:Wiley Periodicals, Inc., American College of Veterinary Internal Medicine
ISSN:0891-6640
Language:English
Publication Type:Journal article
Refereed:Yes
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Medical Bioscience
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Equine metabolic syndrome, Hyperbolic relationship, Insulin dysregulation, Insulin resistance
URN:NBN:urn:nbn:se:slu:epsilon-p-86994
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-86994
Additional ID:
Type of IDID
DOI10.1111/jvim.14799
Web of Science (WoS)000417430600024
ID Code:16688
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:06 Mar 2020 10:28
Metadata Last Modified:08 Apr 2020 21:32

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