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A modified oral sugar test for evaluation of insulin and glucose dynamics in horses

Lindåse, Sanna and Nostell, Katarina and Bröjer, Johan (2016). A modified oral sugar test for evaluation of insulin and glucose dynamics in horses. Acta Veterinaria Scandinavica. 58 , 1-9
[Research article]

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Background: An oral sugar test (OST) using Karo (R) Light Corn Syrup has been developed in the USA as a field test for the assessment of insulin dysregulation in horses but the syrup is not available in Scandinavian grocery stores. The aim of the study was to compare the results of a modified OST between horses with equine metabolic syndrome (EMS) and healthy horses using a Scandinavian commercially available glucose syrup (Dansukker glykossirap). In addition, the effect of breed and the repeatability of the test were evaluated. In the present study, clinically healthy horses (7 Shetland ponies, 8 Icelandic horses, 8 Standardbred horses) and 20 horses of various breeds with EMS underwent the modified OST test. The Icelandic horses and Shetland ponies underwent the OST twice. Insulin and glucose data from the OST were used to calculate peak insulin concentration (Peak(INS)), time to peak insulin concentration (T-peak(INS)), area under the curve for insulin (AUC(INS)) and glucose (AUC(GLU)) as well as whole body insulin sensitivity index (ISICOMP).
Results: Compared to the healthy group, the EMS group had 6-7 times higher geometric mean for Peak(INS) and AUC(INS) and 8 times lower geometric mean for ISICOMP. The EMS group had a delayed T-peak(INS) compared to the healthy group. There was no effect of breed in the group of healthy horses on Peak(INS), T-peak(INS), AUC(INS), AUC(GLU) and ISICOMP. Coefficient of variation for repeated tests was 19.8, 19.0 and 17.6 % for Peak(INS), AUC(INS) and ISICOMP respectively.
Conclusions: The results of the present study demonstrate that the modified OST appears to be a practical and useful diagnostic tool for assessment of insulin dysregulation in the horse. However, to make it possible to establish the most appropriate sampling interval and to evaluate the accuracy of the modified OST, further studies in horses with a variable degree of insulin resistance are needed, where results from the modified OST are compared with quantitative measurements for IS.

Authors/Creators:Lindåse, Sanna and Nostell, Katarina and Bröjer, Johan
Title:A modified oral sugar test for evaluation of insulin and glucose dynamics in horses
Series Name/Journal:Acta Veterinaria Scandinavica
Year of publishing :2016
Page range:1-9
Number of Pages:9
Publisher:BioMed Central
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Horse, Insulin dysregulation, Insulin resistance, Oral sugar test
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Additional ID:
Type of IDID
Web of Science (WoS)000386165300009
ID Code:16689
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:19 Mar 2020 08:35
Metadata Last Modified:08 Apr 2020 21:33

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