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The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects

Leitch, Alistair C. and Abdelghany, Tarek M. and Probert, Philip M. and Dunn, Michael P. and Meyer, Stephanie K. and Palmer, Jeremy M. and Cooke, Martin P. and Blake, Lynsay I. and Morse, Katie and Rosenmai, Anna and Oskarsson, Agneta and Bates, Lucy and Figueiredo, Rodrigo S. and Ibrahim, Ibrahim and Wilson, Colin and Abdelkader, Noha F. and Jones, David E. and Blain, Peter G. and Wright, Matthew C. (2020). The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects. Food and Chemical Toxicology. 136 , 1-14
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Abstract

Ionic liquids are a diverse range of charged chemicals with low volatility and often liquids at ambient temperatures. This characteristic has in part lead to them being considered environmentally-friendly replacements for existing volatile solvents. However, methylimidazolium ionic liquids are slow to break down in the environment and a recent study at Newcastle detected 1 octyl 3 methylimidazolium (M8OI) - an 8 carbon variant methylimidazolium ionic liquid - in soils in close proximity to a landfill site. The current M8OI toxicity database in cultured mammalian cells, in experimental animal studies and in model indicators of environmental impact are reviewed. Selected analytical data from the Newcastle study suggest the soils in close proximity to the landfill site, an urban soil lacking overt contamination, had variable levels of M8OI. The potential for M8OI - or a structurally related ionic liquid - to trigger primary biliary cholangitis (PBC), an autoimmune liver disease thought to be triggered by an unknown agent(s) in the environment, is reviewed.

Authors/Creators:Leitch, Alistair C. and Abdelghany, Tarek M. and Probert, Philip M. and Dunn, Michael P. and Meyer, Stephanie K. and Palmer, Jeremy M. and Cooke, Martin P. and Blake, Lynsay I. and Morse, Katie and Rosenmai, Anna and Oskarsson, Agneta and Bates, Lucy and Figueiredo, Rodrigo S. and Ibrahim, Ibrahim and Wilson, Colin and Abdelkader, Noha F. and Jones, David E. and Blain, Peter G. and Wright, Matthew C.
Title:The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects
Year of publishing :2020
Volume:136
Page range:1-14
Number of Pages:14
Publisher:Elsevier
ISSN:0278-6915
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Pharmacology and Toxicology
Keywords:PBC, Ionic liquids, Liver, C8[mim], Autoimmunity, Xenobiotics
URN:NBN:urn:nbn:se:slu:epsilon-p-104688
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-104688
Additional ID:
Type of IDID
DOI10.1016/j.fct.2019.111069
Web of Science (WoS)000514015300060
ID Code:16743
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:14 Apr 2020 11:45
Metadata Last Modified:14 Apr 2020 11:45

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