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Nanotechnolgy in reproductive biotechnologies: colloid centrifguation for the diagnosis and treatment of fertility in animals

Morrell, Jane (2019). Nanotechnolgy in reproductive biotechnologies: colloid centrifguation for the diagnosis and treatment of fertility in animals. SL Nanomedicine and nanotechnology journal. 2 , 125 , 1-10
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Abstract

Nanotechnology is employed in sperm preparation for assisted reproduction in animals, in the form of colloid centrifugation using coated-silica nanoparticles. The sperm sample is layered on top of the colloid; robust spermatozoa pass through the colloid whereas less robust spermatozoa are retained the colloid/semen interface or within the colloid layer. This method appears to be one of the most suitable sperm preparation techniques for animal semen since it is possible to process large volumes of semen without losing too many spermatozoa, producing highly fertile samples. Robust spermatozoa, with good motility, intact membranes, an unreacted acrosome, and intact chromatin, can be separated from the rest of the ejaculate, thus enhancing fertility when used in reproductive biotechnologies. These spermatozoa tend to produce less hydrogen peroxide than unselected samples, thus enhancing their quality and extending their shelf-life in storage. Furthermore, sperm cryopreservation is enhanced by selection prior to freezing. Sperm samples for artificial insemination, in vitro fertilization or intracytoplasmic sperm injection can be prepared with this method. The method can also be used therapeutically, as an indicator of fertility, to treat fertility issues and for conservation breeding. Furthermore, spermatozoa can be separated from viruses and bacteria in the ejaculate, thus improving biosecurity and potentially reducing the use of antibiotics. The latter can contribute to slowing the development of antimicrobial resistance.

Authors/Creators:Morrell, Jane
Title:Nanotechnolgy in reproductive biotechnologies: colloid centrifguation for the diagnosis and treatment of fertility in animals
Year of publishing :2019
Volume:2
Article number:125
Number of Pages:10
Publisher:Scientific Literature
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Silica colloids, Sperm processing, Artificial insemination, In vitro fertilization, Intracytoplasmic sperm injection, Sperm preservation, Biomimetic sperm selection
URN:NBN:urn:nbn:se:slu:epsilon-p-104648
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-104648
ID Code:16937
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:02 Jun 2020 07:25
Metadata Last Modified:02 Jun 2020 07:25

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