Singh, Abhijeet and Müller, Bettina and Fuxelius, Hans-Henrik and Schnürer, Anna
(2019).
AcetoBase: a functional gene repository and database for formyltetrahydrofolate synthetase sequences.
Database. 2019
, baz142
, 1-14
[Journal article]
![]() |
PDF
- Published Version
1MB |
Official URL: https://acetobase.molbio.slu.se/
Abstract
Acetogenic bacteria are imperative to environmental carbon cycling and diverse biotechnological applications, but their extensive physiological and taxonomical diversity is an impediment to systematic taxonomic studies. Acetogens are chemolithoautotrophic bacteria that perform reductive carbon fixation under anaerobic conditions through the Wood–Ljungdahl pathway (WLP)/acetyl-coenzyme A pathway. The gene-encoding formyltetrahydrofolate synthetase (FTHFS), a key enzyme of this pathway, is highly conserved and can be used as a molecular marker to probe acetogenic communities. However, there is a lack of systematic collection of FTHFS sequence data at nucleotide and protein levels. In an attempt to streamline investigations on acetogens, we developed AcetoBase - a repository and database for systematically collecting and organizing information related to FTHFS sequences. AcetoBase also provides an opportunity to submit data and obtain accession numbers, perform homology searches for sequence identification and access a customized blast database of submitted sequences. AcetoBase provides the prospect to identify potential acetogenic bacteria, based on metadata information related to genome content and the WLP, supplemented with FTHFS sequence accessions, and can be an important tool in the study of acetogenic communities. AcetoBase can be publicly accessed at https://acetobase.molbio.slu.se.
Authors/Creators: | Singh, Abhijeet and Müller, Bettina and Fuxelius, Hans-Henrik and Schnürer, Anna | ||||
---|---|---|---|---|---|
Title: | AcetoBase: a functional gene repository and database for formyltetrahydrofolate synthetase sequences | ||||
Year of publishing : | 2019 | ||||
Volume: | 2019 | ||||
Article number: | baz142 | ||||
Number of Pages: | 14 | ||||
Publisher: | Oxford University Press | ||||
ISSN: | 1758-0463 | ||||
Language: | English | ||||
Publication Type: | Journal article | ||||
Article category: | Scientific peer reviewed | ||||
Version: | Published version | ||||
Copyright: | Creative Commons: Attribution 4.0 | ||||
Full Text Status: | Public | ||||
Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109) (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology | ||||
Keywords: | Acetogenic bacteria, formyltetrahydrofolate synthetase (FTHFS), FTHFS sequences, database, repository | ||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-105822 | ||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-105822 | ||||
Additional ID: |
| ||||
ID Code: | 17147 | ||||
Faculty: | NJ - Fakulteten för naturresurser och jordbruksvetenskap | ||||
Department: | (NL, NJ) > Department of Molecular Sciences | ||||
Deposited By: | SLUpub Connector | ||||
Deposited On: | 29 Jun 2020 07:04 | ||||
Metadata Last Modified: | 29 Jun 2020 07:04 |
Repository Staff Only: item control page