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Structure-Functional Activity Relationship of beta-Glucans From the Perspective of Immunomodulation: A Mini-Review

Han, Biao and Baruah, Kartik and Cox, Eric and Vanrompay, Daisy and Bossier, Peter (2020). Structure-Functional Activity Relationship of beta-Glucans From the Perspective of Immunomodulation: A Mini-Review. Frontiers in Immunology. 11 , 658 , 1-8
[Article Review/Survey]

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Abstract

beta-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of beta-(1,3) and/or beta-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. beta-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, beta-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between beta-glucans' structure and function in relation to their use for immunomodulation.

Authors/Creators:Han, Biao and Baruah, Kartik and Cox, Eric and Vanrompay, Daisy and Bossier, Peter
Title:Structure-Functional Activity Relationship of beta-Glucans From the Perspective of Immunomodulation: A Mini-Review
Year of publishing :2020
Volume:11
Article number:658
Number of Pages:8
Publisher:Frontiers
ISSN:1664-3224
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
Keywords:beta-glucans, structure-function relationship, immunomodulation, molecular structure, molecular weight, solubility
URN:NBN:urn:nbn:se:slu:epsilon-p-105999
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-105999
Additional ID:
Type of IDID
DOI10.3389/fimmu.2020.00658
Web of Science (WoS)000531707400001
ID Code:17171
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Nutrition and Management
Deposited By: SLUpub Connector
Deposited On:02 Jul 2020 11:05
Metadata Last Modified:02 Jul 2020 11:05

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