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Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs

Wille, Michelle and Johansson Wensman, Jonas and Larsson, Simon and Van Damme, Renaud and Theelke, Anna-Karin and Hayer, Juliette and Malmberg, Maja (2020). Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs. Infection, Genetics and Evolution. 82 , 104290 , 1-9
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Abstract

Canine respiratory coronavirus (CRCoV) has been identified as a causative agent of canine infectious respiratory disease, an upper respiratory infection affecting dogs. The epidemiology is currently opaque, with an unclear understanding of global prevalence, pathology, and genetic characteristics. In this study, Swedish privatelyowned dogs with characteristic signs of canine infectious respiratory disease (n = 88) were screened for CRCoV and 13 positive samples (14.7%, 8.4–23.7% [95% confidence interval (CI)]) were further sequenced. Sequenced Swedish CRCoV isolates were highly similar despite being isolated from dogs living in geographically distant locations and sampled across 3 years (2013–2015). This is due to a single introduction into Swedish dogs in approximately 2010, as inferred by time structured phylogeny. Unlike other CRCoVs, there was no evidence of recombination in Swedish CRCoV isolates, further supporting a single introduction. Finally, there were low levels of polymorphisms, in the spike genes. Overall, we demonstrate that there is little diversity of CRCoV which is endemic in Swedish dogs.

Authors/Creators:Wille, Michelle and Johansson Wensman, Jonas and Larsson, Simon and Van Damme, Renaud and Theelke, Anna-Karin and Hayer, Juliette and Malmberg, Maja
Title:Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs
Year of publishing :2020
Volume:82
Article number:104290
Number of Pages:9
Publisher:Elsevier
ISSN:1567-1348
Language:English
Publication Type:Journal article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Canine infectious respiratory disease, Canine respiratory coronavirus, CRCoV, Coronavirus, Evolutionary genetics, Kennel cough
URN:NBN:urn:nbn:se:slu:epsilon-p-106454
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-106454
Additional ID:
Type of IDID
DOI10.1016/j.meegid.2020.104290
ID Code:17202
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
(VH) > Dept. of Clinical Sciences
(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:29 Jun 2020 07:31
Metadata Last Modified:29 Jun 2020 07:31

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