Wille, Michelle and Johansson Wensman, Jonas and Larsson, Simon and Van Damme, Renaud and Theelke, Anna-Karin and Hayer, Juliette and Malmberg, Maja
(2020).
Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs.
Infection, Genetics and Evolution. 82
, 104290
, 1-9
[Research article]
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Abstract
Canine respiratory coronavirus (CRCoV) has been identified as a causative agent of canine infectious respiratory disease, an upper respiratory infection affecting dogs. The epidemiology is currently opaque, with an unclear understanding of global prevalence, pathology, and genetic characteristics. In this study, Swedish privatelyowned dogs with characteristic signs of canine infectious respiratory disease (n = 88) were screened for CRCoV and 13 positive samples (14.7%, 8.4–23.7% [95% confidence interval (CI)]) were further sequenced. Sequenced Swedish CRCoV isolates were highly similar despite being isolated from dogs living in geographically distant locations and sampled across 3 years (2013–2015). This is due to a single introduction into Swedish dogs in approximately 2010, as inferred by time structured phylogeny. Unlike other CRCoVs, there was no evidence of recombination in Swedish CRCoV isolates, further supporting a single introduction. Finally, there were low levels of polymorphisms, in the spike genes. Overall, we demonstrate that there is little diversity of CRCoV which is endemic in Swedish dogs.
Authors/Creators: | Wille, Michelle and Johansson Wensman, Jonas and Larsson, Simon and Van Damme, Renaud and Theelke, Anna-Karin and Hayer, Juliette and Malmberg, Maja | ||||
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Title: | Evolutionary genetics of canine respiratory coronavirus and recent introduction into Swedish dogs | ||||
Series Name/Journal: | Infection, Genetics and Evolution | ||||
Year of publishing : | 2020 | ||||
Volume: | 82 | ||||
Article number: | 104290 | ||||
Number of Pages: | 9 | ||||
Publisher: | Elsevier | ||||
ISSN: | 1567-1348 | ||||
Language: | English | ||||
Publication Type: | Research article | ||||
Article category: | Scientific peer reviewed | ||||
Version: | Published version | ||||
Copyright: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||
Full Text Status: | Public | ||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Pathobiology (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||
Keywords: | Canine infectious respiratory disease, Canine respiratory coronavirus, CRCoV, Coronavirus, Evolutionary genetics, Kennel cough | ||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-106454 | ||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-106454 | ||||
Additional ID: |
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ID Code: | 17202 | ||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||
Department: | (VH) > Department of Biomedical Science and Veterinary Public Health (VH) > Dept. of Clinical Sciences (VH) > Dept. of Animal Breeding and Genetics | ||||
Deposited By: | SLUpub Connector | ||||
Deposited On: | 29 Jun 2020 07:31 | ||||
Metadata Last Modified: | 15 Jan 2021 19:47 |
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