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Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Alim, Md Abdul and Peterson, Magnus and Pejler, Gunnar (2020). Do Mast Cells Have a Role in Tendon Healing and Inflammation? Cells. 9 , 1-15
[Article Review/Survey]

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Abstract

Understanding the links between the tendon healing process, inflammatory mechanisms, and tendon homeostasis/pain after tissue damage is crucial in developing novel therapeutics for human tendon disorders. The inflammatory mechanisms that are operative in response to tendon injury are not fully understood, but it has been suggested that inflammation occurring in response to nerve signaling, i.e., neurogenic inflammation, has a pathogenic role. The mechanisms driving such neurogenic inflammation are presently not clear. However, it has recently been demonstrated that mast cells present within the injured tendon can express glutamate receptors, raising the possibility that mast cells may be sensitive to glutamate signaling and thereby modulate neurogenic inflammation following tissue injury. In this review, we discuss the role of mast cells in the communication with peripheral nerves, and their emerging role in tendon healing and inflammation after injury.

Authors/Creators:Alim, Md Abdul and Peterson, Magnus and Pejler, Gunnar
Title:Do Mast Cells Have a Role in Tendon Healing and Inflammation?
Year of publishing :2020
Volume:9
Page range:1-15
Number of Pages:15
Publisher:MDPI
ISSN:2073-4409
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Cell Biology
Keywords:tendon healing, mast cells, neuropeptides, inflammation, tendon pain
URN:NBN:urn:nbn:se:slu:epsilon-p-106754
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-106754
Additional ID:
Type of IDID
DOI10.3390/cells9051134
Web of Science (WoS)000539340200068
ID Code:17285
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:19 Aug 2020 12:11
Metadata Last Modified:19 Aug 2020 12:11

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