Alim, Md Abdul and Peterson, Magnus and Pejler, Gunnar
(2020).
Do Mast Cells Have a Role in Tendon Healing and Inflammation?
Cells. 9
, 1-15
[Article Review/Survey]
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Abstract
Understanding the links between the tendon healing process, inflammatory mechanisms, and tendon homeostasis/pain after tissue damage is crucial in developing novel therapeutics for human tendon disorders. The inflammatory mechanisms that are operative in response to tendon injury are not fully understood, but it has been suggested that inflammation occurring in response to nerve signaling, i.e., neurogenic inflammation, has a pathogenic role. The mechanisms driving such neurogenic inflammation are presently not clear. However, it has recently been demonstrated that mast cells present within the injured tendon can express glutamate receptors, raising the possibility that mast cells may be sensitive to glutamate signaling and thereby modulate neurogenic inflammation following tissue injury. In this review, we discuss the role of mast cells in the communication with peripheral nerves, and their emerging role in tendon healing and inflammation after injury.
| Authors/Creators: | Alim, Md Abdul and Peterson, Magnus and Pejler, Gunnar | ||||||
|---|---|---|---|---|---|---|---|
| Title: | Do Mast Cells Have a Role in Tendon Healing and Inflammation? | ||||||
| Series Name/Journal: | Cells | ||||||
| Year of publishing : | 2020 | ||||||
| Volume: | 9 | ||||||
| Page range: | 1-15 | ||||||
| Number of Pages: | 15 | ||||||
| Publisher: | MDPI | ||||||
| ISSN: | 2073-4409 | ||||||
| Language: | English | ||||||
| Publication Type: | Article Review/Survey | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Cell Biology | ||||||
| Keywords: | tendon healing, mast cells, neuropeptides, inflammation, tendon pain | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-106754 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-106754 | ||||||
| Additional ID: |
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| ID Code: | 17285 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Dept. of Anatomy, Physiology and Biochemistry | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 19 Aug 2020 12:11 | ||||||
| Metadata Last Modified: | 15 Jan 2021 19:03 |
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